HGF-rs12536657 and Ocular Biometric Parameters in Hyperopic Children, Emmetropic Adolescents, and Young Adults: A Multicenter Quantitative Trait Study

Table 3

Univariate generalized estimating equation method of topographic measurements with HFG rs12536657 under an additive genetic model adjusted for age and gender.

	Genotype rs12536657	Coef.	95% CI for slope
			Lower	Upper
Kmean (TOP) (D)					0.010
	G/G (ref.)	41.88
	G/A	0.32	0.04	0.60	0.023
	A/A	0.76	0.12	1.40	0.020
Kflat (TOP) (D)					0.019
	G/G (ref.)	40.89
	G/A	0.31	0.02	0.60	0.036
	A/A	0.69	0.06	1.31	0.031
Ksteep (TOP) (D)					0.007
	G/G (ref.)	42.87
	G/A	0.34	0.05	0.63	0.021
	A/A	0.83	0.16	1.51	0.015
ACD (TOP) (mm)					0.787
	G/G (ref.)	2.80
	G/A	0.00	−0.06	0.05	0.875
	A/A	−0.04	−0.16	0.07	0.489
WW (TOP) (mm)					0.424
	G/G (ref.)	11.98
	G/A	−0.02	−0.10	0.07	0.703
	A/A	−0.13	−0.32	0.07	0.195
CCT (TOP) (µm)					0.191
	G/G (ref.)	578.63
	G/A	−6.39	−13.37	0.60	0.073
	A/A	0.04	0.04	17.45	0.996
Apical CT (TOP) (µm)					0.812
	G/G (ref.)	610.27
	G/A	−3.70	−14.98	7.58	0.520
	A/A	−0.98	−23.72	21.77	0.933

TOP: topography measurements; K_flat: anterior flat keratometry (diopters); K_steep: anterior steep keratometry (diopters); K_mean: anterior mean keratometry; ACD: anterior chamber depth (mm); WW: white-to-white diameter (mm); CCT: central corneal thickness; apical CT: apical corneal thickness. For reference categories, coefficient presented is the intercept (mean of ref. category), and for other categories, it is the slope (mean difference).