HGF-rs12536657 and Ocular Biometric Parameters in Hyperopic Children, Emmetropic Adolescents, and Young Adults: A Multicenter Quantitative Trait Study

Table 4

Univariate generalized estimating equation method to analyze association of refractive and biometric measurements with HFG rs12536657 under an additive genetic model adjusted for age and gender.

	Genotype rs12536657	Coef	95% CI for slope
			Lower	Upper
SE (D)					0.930
	G/G (ref.)	8.50
	G/A	0.04	−0.27	0.34	0.817
	A/A	−0.07	−0.64	0.49	0.796
Cyl (D)					0.857
	G/G (ref.)	−1.38
	G/A	0.01	−0.12	0.14	0.885
	A/A	−0.05	−0.26	0.15	0.618
AL (BIOM) (mm)					0.236
	G/G (ref.)	20.29
	G/A	−0.12	−0.28	0.05	0.166
	A/A	−0.22	−0.58	0.14	0.231
Kmean (BIOM) (D)					0.016
	G/G (ref.)	42.11
	G/A	0.29	0.02	0.56	0.033
	A/A	0.70	0.08	3.75	0.026
Kflat (BIOM) (D)					0.037
	G/G (ref.)	41.04
	G/A	0.31	−0.01	0.55	0.055
	A/A	0.63	0.00	1.25	0.049
Ksteep (BIOM) (D)					0.009
	G/G (ref.)	43.17
	G/A	0.31	0.03	0.59	0.027
	A/A	0.78	0.15	1.41	0.015
ACD (BIOM) (mm)					0.319
	G/G (ref.)	3.15
	G/A	−0.01	−0.07	0.04	0.680
	A/A	−0.08	−0.19	0.02	0.132

SE: spherical equivalent; Cyl: cylinder; BIOM: IOL master measurements; AL: axial length (mm); K_flat: anterior flat keratometry (diopters); K_steep: anterior steep keratometry (diopters); K_mean: anterior mean keratometry; ACD: anterior chamber depth (mm). For reference categories, coefficient presented is the intercept (mean of ref. category), and for other categories, it is the slope (mean difference).