Repressed Wnt Signaling Accelerates the Aging Process in Mouse Eyes

Figure 3

Signs of iris stromal atrophy in KR/sFRP1 mice. Overall surface texture of irises for control (a) and KR/sFRP1 (b) mice. High-magnification images revealed the difference between the two (c, d). In the control eyes, the surface area between vessels was smooth and uniform. In the KR/sFRP1 eyes, the blood vessels were bulging and tortuous. Iris angiography images of the control (e) and KR/sFRP1 (f) mice further demonstrate tortuous vessels. The atrophic findings of the KR/sFRP1 irises further demonstrate ocular findings consistent with aging.