Protective Effects of Intravitreal Injection of the Rho-Kinase Inhibitor Y-27632 in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rAION)

Figure 2

Cross-sectional OCT images displaying GCC thickness at 2 days and 28 days after induction. (a) Circular scan around the optic disc showing GCC thickness at 2 days after induction. (b) Quantification of GCC thickness at 2 days after induction. The mean GCC thickness in the Y-27632-treated group was significantly lower than that of the PBS-treated group at day 2 (n = 12 per group). The asterisk indicates , as determined by the Kruskal–Wallis test. (c) Circular scan around the optic disc showing GCC thickness at 28 days after induction. (d) Quantification of GCC thickness at 28 days after induction. The mean GCC thickness in the Y-27632-treated group was significantly higher than that of the PBS-treated group after 28 days but was not significantly different from that of the sham group (n = 12 per group). The asterisk indicates , as determined by the Kruskal–Wallis test.

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