Systemic Factors Associated with Treatment Response in Diabetic Macular Edema

Table 3

Association of various systemic factors with change in central subfield thickness (CST) and change in logMAR visual acuity (N = 33), (Mann–Whitney U test).

S/N	Systemic factor		Reduction in CST		value	Change in logMAR visual acuity		value
			Mean	SD		Mean	SD
1	IHD	No (n = 23)	98.43	165.38	0.3371	0.013	0.239	0.7479
		Yes (n = 10)	44.3	105.23		0.006	0.193
2	On dialysis	No (n = 30)	77.63	145.77	0.7542	0.006	0.234	0.2105
		Yes (n = 3)	126	222.7		0.06	0.053
3	Systolic BP	≤140 (n = 11)	71.73	180.23	0.4337	−3.05	0.29	0.09532
		>140 (n = 22)	87.18	137.18		0.016	0.192
4	Diastolic BP	≤90 (n = 29)	79.31	155.30	0.6994	0.283	0.228	0.1492
		<90 (n = 4)	101.75	122.09		−0.115	0.160
5	Creatinine	≤120 (18)	77.61	134.9	0.6255	−0.008	0.212	0.2582
		<120 (n = 15)	87.3	171.47		0.033	0.243
6	eGFR	>90 (n = 8)	82.13	172.0	0.8831	0.058	0.267	0.7961
		<90 (n = 25)	82	146.44		−0.004	0.212
6	Total cholesterol	≤5.2 (n = 24)	72.67	147.39	0.7464	−0.018	0.197	0.2905
		>5.2 (n = 9)	107.25	163.7		0.087	0.283
7	Triglycerides	</ = 2.2 (n = 22)	91.14	166.77	0.9239	0.054	0.244	0.1645
		>2.2 (n = 11)	63.82	114.99		−0.075	0.153
8	HDL cholesterol	≥1 (n = 27)	69.67	134.7	0.7794	0.002	0.208	0.6322
		<1 (n = 6)	137.67	213.2		0.05	0.307
9	LDL cholesterol	</ = 3.3 (n = 25)	69.76	145.02	0.5015	−0.017	0.192	0.2627
		>3.3 (n = 8)	120.38	169.67		0.098	0.301
10	LDL:  total cholesterol	≤3.5 (n = 14)	41.86	75.49	0.8841	−0.054	0.157	0.5558
		>3.5 (n = 19)	111.63	183.86		0.059	0.256
11	HbA1c	≤7 (n = 15)	130.13	158.44	0.012	0.001	0.259	0.8821′
		>7 (n = 18)	41.94	134.32		0.019	0.197
12	Serum VEGF	≤308 (n = 10)	41.1	132.49	0.1894	0.008	0.065	0.6879
		>308 (n = 23)	99.83	156.64		0.012	0.267

CST, central subfield thickness; IHD, ischemic heart disease; BP, blood pressure; eGFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; LDL, low-density lipoproteins; HbA1c, glycosylated hemoglobin; VEGF, vascular endothelial growth factor.