Safety of Intravitreal Injection of Biosimilar of Aflibercept in Rabbit Eyes

Table 1

Comparison of the amplitudes and latent times of rod responses from the aflibercept-treated rabbits and saline-treated rabbits and Eylea-treated rabbits.

Groups	a-wave amplitude	b-wave amplitude	a-wave latent time	b-wave latent time
48 hours
Saline	−43.5 ± 8.8	139.4 ± 19.2	14.7 ± 0.7	35.6 ± 1.2
Eylea	−44.7 ± 5.9	120.8 ± 13.6	13.7 ± 0.6	36.1 ± 1
Aflibercept	−48.9 ± 20.3	158.6 ± 64.5	14.6 ± 0.6	37.7 ± 1.7
value
Aflibercept/saline	0.60	0.32	0.77	0.82
Aflibercept/Eylea	0.73	0.62	0.81	0.86
1 week
Saline	−44 ± 8.1	149.9 ± 27.2	14.1 ± 0.6	35.1 ± 1.6
Eylea	−38.3 ± 5.8	116.5 ± 11.7	13.9 ± 0.1	32.7 ± 1.5
Aflibercept	−46.4 ± 9.9	151.4 ± 32.7	14.3 ± 0.8	36 ± 1.3
value
Aflibercept/saline	0.85	0.89	0.84	0.63
Aflibercept/Eylea	0.76	0.27	0.82	0.47
2 weeks
NS	−33.6 ± 8.4	125 ± 28.3	14.3 ± 0.7	35.9 ± 1.5
Eylea	−44.5 ± 1.7	131.5 ± 22.1	13.2 ± 0.5	33.1 ± 1.5
Aflibercept	−37.8 ± 10.1	133.2 ± 40.2	14.4 ± 1.1	35.8 ± 1.4
value
Aflibercept/saline	0.29	0.44	0.97	0.96
Aflibercept/Eylea	0.26	0.83	0.79	0.71
4 weeks
NS	−41.6 ± 13.3	140.3 ± 20.5	14.4 ± 0.6	37.2 ± 2.3
Eylea	−32.9 ± 8.5	105.4 ± 11.7	14.1 ± 0.1	34.3 ± 1.8
Aflibercept	−38.4 ± 20.5	140.9 ± 89.6	15.4 ± 1.1	40.2 ± 2.2
value
Aflibercept/saline	0.23	0.98	0.45	0.55
Aflibercept/Eylea	0.69	0.21	0.62	0.38

Data are mean ± SD Mann–Whitney U-test.