Safety of Intravitreal Injection of Biosimilar of Aflibercept in Rabbit Eyes

Table 3

The amplitudes and latent times of ERG waves from the Eylea-treated rabbits.

Groups	a-wave amplitude	b-wave amplitude	a-wave latent time	b-wave latent time
48 hours
Pretreatment	−47.8 ± 3	140.1 ± 14.7	13.1 ± 0.5	37.5 ± 1.5
Posttreatment	−44.7 ± 5.9	120.8 ± 13.6	13.7 ± 0.6	36.1 ± 1
Difference in %	Decrease 6.4%	Decrease 13.8%	Increase 4.5%	Decrease 3.8%
1 week
Pretreatment	−41.8 ± 3	137.1 ± 14.7	14.1 ± 0.5	34.1 ± 1.5
Posttreatment	−38.3 ± 5.8	116.5 ± 11.7	13.9 ± 0.1	32.7 ± 1.5
Difference in %	Decrease 8.4 %	Decrease 15.1%	Decrease 1.5%	Decrease 4.2%
2 weeks
Pretreatment	−41.8 ± 3	126.12 ± 14.7	14.0 ± 0.5	32.4 ± 1.9
Posttreatment	−44.5 ± 1.7	131.5 ± 22.1	13.2 ± 0.5	33.1 ± 1.5
Difference in %	Increase 6.4%	Increase 4.2%	Decrease 5.8%	Increase 2.1%
4 weeks
Pretreatment	−36.8 ± 3	117.1 ± 14.3	14.9 ± 0.8	36.7 ± 1.4
Posttreatment	−32.9 ± 8.5	105.4 ± 11.7	14.1 ± 0.1	34.3 ± 1.8
Difference in %	Decrease 10.5%	Decrease 10%	Decrease 5.4%	Decrease 6.6%

Data are mean ± SD.