Identification of Key Genes and Pathways Associated with Age-Related Macular Degeneration

Figure 5

Upstream and regulator effect in RPE/choroid between AMD patients and controls. Genes in green were downregulated, and genes in red were upregulated. The deeper the color, the higher the degree of downregulation. Images in blue indicate that the decreased expression level of the upstream genes might suppress the expression of the downstream genes. Images in orange mean the decreased expression level of the upstream genes may lose their function as inhibitors of downstream effects. Full line in blue means the upstream genes can definitely regulate the expression of the downstream genes and effects. Lines in gray mean the upstream genes may have no effects on the regulation of downstream genes and effects.