Epidemiological Study of Uveal Melanoma from US Surveillance, Epidemiology, and End Results Program (2010–2015)

Table 3

Univariate analysis of overall and disease-specific survival (1142 cases included).

Characteristic	value for log rank		Cumulative survival rate at 5 y, %
	OS	DSS	OS	DSS
Overall			61.8	66.5
Age range^a
Young	Reference	Reference	71.4	68.9
Mid	0.001	0.798	61.0	72.6
Elder	<0.001	0.01	31.9	59.7
Sex
Female	Reference	Reference	62.9	68.0
Male	0.166	0.379	60.8	65.2
Race
White	Reference	Reference	60.2	65.5
Others	0.042	0.049	84.4	91.1
Origin
Hispanic	Reference	Reference	57.6	66.7
Non-Hispanic	0.212	0.143	61.2	61.4
Laterality
Right	Reference	Reference	60.2	67.9
Left	0.698	0.475	61.7	65.2
AJCC stage
I	Reference	Reference	88.0	93.6
II	<0.001	<0.001	67.4	72.9
III	<0.001	<0.001	46.3	49.5
IV	<0.001	<0.001	13.7^b	14.4 ^b
Summary stage
Localized	Reference	Reference	64.3	69.3
Regional	0.013	0.02	60.1	63.4
Distant	<0.001	<0.001	13.5^b	11.2 ^b
Metastasis at diagnosis
None	Reference	Reference	62.6	67.4
Distant	<0.001	< 0.001	13.5^b	11.2 ^b
Surgery
Performed	Reference	Reference	54.7	59.5
Not performed	<0.001	<0.001	67.3	71.8
Radiation
Performed	Reference	Reference	69.0	74.2
Not performed	<0.001	<0.001	52.6	55.3
Chemotherapy
Performed	Reference	Reference	56.0	56.0
Not performed	0.160	0.059	61.3	66.8
Marital status
Married	Reference	Reference	62.1	66.1
Others	0.824	0.61	61.4	67.1

Abbreviations: OS, overall survival; DSS, disease-specific survival; AJCC, American Joint Committee on Cancer. ^aAge stratification was different in OS and DSS, according to results of X-tile process. ^bDue to lack of patient sample, the longest follow-up time was 46 months. We used the latest survival data instead of accurate 5-year accumulative survival rate. Bold letter indicates that measurements are statistically significant compared with references () ; ; .