Epidemiological Study of Uveal Melanoma from US Surveillance, Epidemiology, and End Results Program (2010–2015)

Table 4

Cox proportional hazard ratio (HR) for overall and disease-specific survival (1142 cases included).

Characteristic	Overall survival		Disease-specific survival
	HR (95% CI)	value	HR (95% CI)	value
Age range^a		<0.001		0.001
Young	Reference		Reference
Mid	1.532 (1.122–2.093)	0.007	1.005 (0.627–1.608)	0.985
Elder	3.670 (2.500–5.389)	<0.001	1.721 (1.107–2.674)	0.016
Race		0.133		0.09
Others	Reference		Reference
White	2.151 (0.791–5.851)	0.133	2.715 (0.867–8.598)	0.090
AJCC stage		0.002		0.002
I	Reference		Reference
II	5.098 (2.204–11.791)	<0.001	9.174 (3.103)	<0.001
III	4.347 (1.738–10.876)	0.003	8.337 (2.617–26.553)	<0.001
IV	N/A^b	N/A^b	N/A^b	N/A^b
Summary stage		0.999		0.985
Localized	Reference		Reference
Regional	0.969 (0.505–1.875)	0.924	1.074 (0.526–2.195)	0.845
Distant	0.974 (0.428–2.218)	0.950	1.173 (0.474–2.903)	0.730
Metastasis at diagnosis		0.613		0.49
None	Reference		Reference
Distant	0.810 (0.358–1.834)	0.613	1.339 (0.584–3.071)	0.49
Surgery		0.829		0.548
Not performed	Reference		Reference
Performed	0.890 (0.554–1.429)	0.63	0.749 (0.443–1.268)	0.282
Radiation		0.080		0.024
Not performed	Reference		Reference
Performed	0.657 (0.410–0.1.052)	0.080	0.551 (0.329–0.925)	0.024
Chemotherapy		0.204		0.520
Not performed	Reference		Reference
Performed	0.611 (0.285–1.307)	0.204	0.779 (0.364–1.667)	0.520

Abbreviations: AJCC, American Joint Committee on Cancer. ^aAge stratification was different in OS and DSS, according to results of X-tile process. ^bValues were smaller in subgroup and hence unavailable. Bold letter indicates that measurements are statistically significant compared with references (). ; ; .