Clinical Presentations and Outcomes of Retinoblastoma Patients in relation to the Advent of New Multimodal Treatments: A 12-Year Report from Single Tertiary Referral Institute in Thailand

Table 3

Treatment modalities for intraocular and extraocular tumors according to the International Retinoblastoma Staging System (IRSS).

Treatment modalities, n = 124	IRSS staging, eyes
	0		I		II		III		IV
	Unilateral	Bilateral	Unilateral	Bilateral	Unilateral	Bilateral	Unilateral	Bilateral	Unilateral	Bilateral
Globe salvage treatment^1	12	48	—	—	—	—	—	—	—	—
CRD + enucleation	—	—	3	15	—	—	—	—	—	—
CRD + IAC + enucleation	—	—	4	4	—	—	—	—	—	—
CRD + EBRT + enucleation	—	—	—	1	—	—	1	—	1	—
CRD + IAC + plaque + enucleation	—	—	1	1	—	—	—	—	—	—
CRD + IAC + IVT + plaque + enucleation	—	—	1	—	—	—	—	—	—	—
CRD + IVT + plaque + enucleation	—	—	—	1	—	—	—	—	—	—
CRD + exenteration	—	—	2	—	—	—	—	—	—	—
CRD + exenteration + EBRT	—	—	—	—	—	—	1	—	—	—
IAC + enucleation	—	—	2	1	—	—	—	—	—	—
IAC + IVT + plaque + enucleation	—	—	1	—	—	—	—	—	—	—
Primary enucleation (in our center/from referral hospital)	—	—	9 (8/1)	14 (8/6)	—	—	—	—	—	1 (0/1)
Total	12	48	23	37	0	0	2	0	1	1

¹Detailed treatment modalities are listed in Table 1. IRSS = International Retinoblastoma Staging System; CRD = chemoreduction; IAC = intra-arterial chemotherapy; EBRT = external beam radiation therapy; IVT = intravitreal chemotherapy.