Epidemiology and Survival Outcomes for Eyelid Primary Malignant Melanoma: An Analysis of 1397 Cases in the SEER Database

Table 2

Univariate analysis of factors affecting 5-year and 10-year OS and DSS of eyelid PMM.

Characteristics	OS		Log rank	DSS		Log rank
	5-year	10-year	value	5-year	10-year	value
Overall	70.5	51.8		90.6	86.1
Sex
Male	67.3	49.4	Reference	89.5	86.2	Reference
Female	74.1	54.4	0.068	99.2	97.6	0.317
Race
White	69.8	50.8	Reference	90.2	85.7	Reference
Others	90.1	81.1	0.009	100	96.0	0.052
Ethnicity
Hispanic	72.7	63.7	Reference	91.9	89.3	Reference
Non-Hispanic	70.4	51.1	0.542	90.5	85.9	0.714
Age, y
<40	94.2	90.9	Reference	95.4	92.0	Reference
40–59	86.8	75.7	0.005	93.0	86.6	0.186
60–79	76.0	57.6	<0.001	91.8	88.5	0.342
80+	43.9	13.7	<0.001	84.3	79.9	0.007
Laterality
Left	72.2	53.4	Reference	91.6	88.0	Reference
Right	69.5	50.8	0.501	89.2	83.9	0.190
Histology
Malignant melanoma, NOS	69.3	51.8	Reference	88.8	84.8	Reference
LMM	73.5	54.2	0.692	99.0	94.8	<0.001
SSM	82.1	58.8	0.003	95.4	89.2	0.006
NM	56.5	36.7	0.001	76.4	71.5	0.004
AJCC stage
I	79.3	61.1	Reference	97.3	93.9	Reference
II	64.4	53.7	<0.001	80.8	76.6	<0.001
III	57.0	46.0	<0.001	75.9	N/A	<0.001
IV	40.0	20.0	<0.001	50.3	N/A	<0.001
Stage at diagnosis
Localized	75.9	56.1	Reference	94.7	90.8	Reference
Regional	39.8	26.2	<0.001	62.7	54.5	<0.001
Distant	28.4	17.0	<0.001	41.4	33.1	<0.001
Metastasis at diagnosis
None	72.1	N/A	Reference	92.9	N/A	Reference
Distant	40.0	N/A	<0.001	50.0	N/A	<0.001
Surgery
Yes	71.9	53.1	Reference	91.1	86.6	Reference
No	60.7	28.6	<0.001	83.6	77.2	0.009
Radiation chemotherapy
Yes	59.9	37.9	Reference	74.2	49.5	Reference
No	71.5	52.2	<0.001	91.1	87.3	<0.001
Chemotherapy
Yes	69.6	46.4	Reference	77.4	46.4	Reference
No	70.6	51.8	0.425	90.8	86.6	<0.001

OS, overall survival; DSS, disease-specific survival; PMM, primary malignant melanoma; NOS, not otherwise specified; LMM, lentigo malignant melanoma; SSM, superficial spreading melanoma; NM, nodular melanoma; AJCC, American Joint Committee on Cancer. Bold letters indicate statistical significance compared with references (). ; ; .