Journal of Ophthalmology

Research Article

Effect of Repeated Intravitreal Ranibizumab and Aflibercept Injections on the Cornea in Patients with Age-Related Macular Degeneration

Table 2

Wilcoxon test for the endothelium cell density (ECD), the percentage of hexagonal cells (% Hex), and the coefficient of variation of cell size (CoV) before and after ranibizumab injections (RI) and aflibercept injections (AI).


	Ranibizumab injections (RI)	Aflibercept injections (AI)
	value	value

ECD before and after 1^st injection	0.022	<0.0001
ECD before and after 2^nd injection	0.041	<0.0001
ECD before and after 3^rd injection	0.0007	<0.0001
ECD before and 6 months after 1^st injection	0.000019	<0.0001
% Hex before and after 1^st injection	0.0043	0.038
% Hex before and after 2^nd injection	0.000002	0.024
% Hex before and after 3^rd injection	<0.0001	0.0018
% Hex before and 6 months after 1^st injection	<0.0001	0.00091
CoV before and after 1^st injection	0.14	0.72
CoV before and after 2^nd injection	0.000004	0.60
CoV before and after 3^rd injection	0.002	0.0073
CoV before and 6 months after 1^st injection	0.0003	0.0083