Effect of the Duration of Intraretinal or Subretinal Fluid on the Response to Treatment in Undertreated Age-Related Macular Degeneration

Table 4

Differences between diminished or maintained effect among IRF continuous over 10 months group.

	Effect maintained	Effect diminished	value
Number (eye)	19/28 (67.9%)	9/28 (32.1%)
Longest IRF (months)	26.78 ± 20.96 (range, 10–70)	53.56 ± 29.05 (range, 18–95)	0.005^※
Injection number during longest IRF	3.68 ± 1.38 (range, 2–7)	11.33 ± 7.50 (range, 7–27)	＜0.0001^※
Injection span (months)	7.59 ± 7.18 (range, 3.3–35)	6.55 ± 6.71 (range, 2.4–23)	0.192^※
PDT previous longest IRF (eyes)	4/19 (21.1%)	2/9 (22.2%)	0.673
PDT during longest IRF (eyes)	0/19 (0%)	2/9 (18.2%)	0.178
Total added IRF previous longest IRF (months)	7.05 ± 9.48 (range, 0–37.5)	0.5 ± 0.90 (range, 0–2.5)	0.018^※
Total added SRF previous longest IRF (months)	9.20 ± 9.52 (range, 0–29.5)	7.44 ± 10.58 (range, 0–28.5)	0.322^※
Type of CNV (occult or PCV/others)	10/19 (53%) (PCV 8; occult 2)	8/9 (89%) (PCV 4; occult 4)	0.147^※

Nine eyes with no injection or one injection were not included. Total added SRF was 0 if the longest IRF was the first IRF. ※Mann–Whitney U test. Fisher’s exact test.