Research Article

Comparison of 27-Gauge and 25-Gauge Microincision Vitrectomy Surgery for the Treatment of Vitreoretinal Disease: A Systematic Review and Meta-Analysis

Table 1

Characteristics of involved studies.

Included studiesDesignDiseaseLocationNo. of eyes 27G/25GAge (year) mean ± SD 27G/25GFollowup (months)Complications (eyes) 27G/25G

Reibaldi et al. [21]Prospective randomized comparative studyERMItaly40/3966 ± 6/64 ± 6
 = 0.14
12IRB: 0/3
VH: 2/3
Hypotony: 1/2
ERM recurrence: 3/2
Mitsuiet al. [15]Prospective nonrandomized comparative studyERMJapan32/3668.9 ± 5.3/65.4 ± 11.4
 = 0.33
6Hypotony: 3/4
Takashina et al. [17]Retrospective randomized comparative studyERMJapan59/8872.9 ± 6.3/71.3 ± 7.9
 : NA
1NA
Rizzo et al. [9]Prospective nonrandomized comparative studyRRDItaly20/2064.7 ± 9.7/62.4 ± 9.8
 : NA
6IRB: 2/1
Choroidal detachment: 1/0
RD: 2/3
Intraocular hypertension: 1/2
Naruse et al. [29]Retrospective nonrandomized clinical trialERMJapan100/10067.6 ± 9.6/69.4 ± 8.9
 = 0.25
6RD: 0/1
VH: 1/1
Hypotony: 2/6
Intraocular hypertension: 4/10
Romanoet al. [23]Prospective randomized comparative studyRRDItaly15/1558 ± 8/59 ± 11
 = 0.82
6RD: 1/1
VH: 1/0
Intraocular hypertension: 0/2
Liet al. [30]Retrospective nonrandomized clinical trial.RRDChina34/5858.5 ± 13.3/54.1 ± 12.5
 = 0.1
6RD: 3/3
IRB: 1/2
Hypotony: 0/1
Intraocular hypertession: 0/1
Lubinski et al [24]Prospective randomized comparative studyERMPoland30/3065.40 ± 4.29/67.50 ± 4.18
 = 0.052
6RD: 1/1
Macular hole: 1/0
Hypotony: 3/7
Otsuka et al. [25]Retrospective nonrandomized clinical trialRRDJapan30/3259 ± 13/55 ± 9
 = 0.15
6RD: 1/2
Sborgia et al. [31]Prospective randomized comparative studyRRDItaly42/4659.9 ± 9.2/61.7 ± 8.7
 = 0.35
12RD: 4/2
Choroidal detachment: 1/0
ERM: 5/2
CME: 2/1
Veritti et al. [26]Prospective randomized comparative studyRRDItaly37/3763.9 ± 13.5/63.1 ± 12.5
 = 0.8
6RD: 4/3
Hypotony: 0/2
Intraocular hypertension: 4/5
Wound suture: 3/11

CME: cystoid macular edema; ERM: epiretinal membrane; IRBs: iatrogenic retinal breaks; RRD: rhegmatogenous retinal detachment; VH: vitreous hemorrhage; hypotony was defined as IOP < 6 mmHg and intraocular hypertension was defined as IOP > 21 mmHg.