A Review of Complicated Cataract in Retinitis Pigmentosa: Pathogenesis and Cataract Surgery

Table 1

Changes of cytokines between RP patients and the control group in different fluid.

Author	Year	Test group	Control group	IL	Chemokines	GF	MMP and other cytokines
Okita et al. [35]	2020	Serum in RP patients	Serum in without RP	IL-2↑, IL-10↑, IL-17↑	IL-8↑, RANTES↑	NA	n.s.
Lu et al. [34]	2020	AH in RP patients	AH in ARC	n.s.	IL-8↑, MCP-1↑, IP-10↑	HGF↑, PDGF-AA↑	MMP-2↑, MMP3↑, MMP-7↑, MMP-8↑, PAI-1↑, TSP-2↑, BMP-4↓
Ten Berge et al. [33]	2019	IOF in RP patients	RP paired serum	IL-2↑, IL-6ra↓, IL-6↑, IL-23↓	MCP-1↑, TARC↓	PlGF↑, VEGF↓	n.s.
Yoshida et al. [31]	2013	AH in RP patients	AH in cataract	n.s.	IL-8↑, TARC↑, MCP-1↑	NA	n.s.
		Vitreous fluid in RP patients	Vitreous fluid in iERM patients	IL-1α↑, IL-1β↑, IL-2↑, IL-4↑, IL-6↑, IL-10↑	IL-8↑, TARC↑, MCP-1↑, MCP-2↑, GRO-α↑, I-309↑, IP-10↑	NA	IFN-γ↑
Salom et al. [37]	2010	AH in RP patients	AH in cataract	NA	NA	HGF↑	NA
Salom et al. [36]	2008	AH in RP patients	AH in cataract	NA	NA	VEGF-A↓	NA

All data in the list were considered statistically significant (-value < 0.05). RP = retinitis pigmentosa; IL = interleukin; GF = growth factor; MMP = matrix metalloproteinase; RANTES = regulated activation normal T-cell expressed and secreted; NA = not available; n.s. = not statistically significant (); AH = aqueous humor; ARC = age-related cataract; MCP-1 = monocyte chemotactic protein 1; IP-10 = interferon γ inducible protein 10; HGF = hepatocyte growth factor; PDGF-AA = platelet-derived growth factor AA; PAI-1 = plasminogen activator inhibitor-1; TSP-2 = thrombospondin-2; BMP-4 = bone morphogenetic protein-4; IOF = intraocular fluid; TARC = thymus- and activation-regulated chemokine; PlGF = placental growth factor; VEGF = vascular endothelial growth factor; iERM = idiopathic epiretinal membrane; Gro-α = growth related oncogene-α; IFN-γ = interferon gamma.