The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

Figure 3

1. The immune response is maintained by the IL-23-GM-CSF axis. 2. IL-17A and IL-17F can promote the production of eosinophils CXCL1, IL-8, and CCL4, as well as IL-1β and IL-6. 3. IL-17A is involved in the pathophysiology of allergies by increasing the ability of IL-13 to activate signaling pathways such as intracellular STAT-6. IL-17A protein expression synergizes with IL-13. 4. Th17 cells have been shown to help B cell differentiation and to play a key role in the formation of ectopic lymphoid follicles in the target organ.