The Influence of Marital Status on the Survival of Patients with Uveal Melanoma

Table 2

Univariate and multivariate analysis for OS in uveal melanoma patients.

Variables	Median OS (month)	Univariate analysis		Multivariate analysis
		Log-rank χ^2	value	HR (95% CI)	value
Gender					<0.001
Male	44	7.138	0.008	Reference
Female	47			0.770 (0.682, 0.870)
Age at diagnosis		77.138	<0.001		<0.001
<40	51.5			Reference
40–59	54			1.774 (1.208, 2.604)	0.003
60–79	43			3.136 (2.150, 4.575)	<0.001
≥80	34			7.065 (4.762, 10.482)	<0.001
Race		16.063	0.001		0.001
Black	39			Reference
White	45			2.307 (0.742, 7.178)	0.149
Others	43.5			2.321 (0.670, 8.042)	0.184
Unknown	74			0.561 (0.125, 2.514)	0.450
Diagnosis year		3.783	0.286		0.058
2004–2006	109
2007–2009	80				0.025
2010–2012	46				0.023
2013–2015	15				0.856
Marital status		77.138	<0.001		0.003
Married	46			Reference
Single	44			1.203 (1.005, 1.440)	0.044
Divorced/separated	43			1.305 (1.065, 1.600)	0.010
Widowed	41			1.300 (1.086, 1.556)	0.004
SEER stage		213.756	<0.001		<0.001
Localized	45			Reference
Regional	50			1.985 (1.703, 2.313)	<0.001
Metastatic	13			5.163 (3.681, 7.242)	<0.001
Surgery		81.276	<0.001		<0.001
Yes	38			Reference
No/unknown	47			0.588 (0.523, 0.661)	<0.001
Median household income		9.447	0.024		0.145
Quartile 1	45
Quartile 2	42				0.076
Quartile 3	44.5				0.970
Quartile 4	49				0.046
Registry sites		4.391	0.222		0.015
West	43			Reference
Midwest	46.5			0.861 (0.715, 1.036)	0.113
South	46			1.056 (0.904, 1.234)	0.492
Northeast	54			0.796 (0.669, 0.947)	0.010