The Influence of Marital Status on the Survival of Patients with Uveal Melanoma

Table 3

Univariate and multivariate analysis for CSS in uveal melanoma patients.

Variables	Median CCS (month)	Univariate analysis		Multivariate analysis
		Log-rank χ^2	value	HR (95% CI)	value
Gender					0.023
Male	47	4.164	0.041	Reference
Female	50			0.767 (0.610, 0.965)
Age at diagnosis		21.099	<0.001		<0.001
<40	51.5			Reference
40–59	57			1.221 (0.680, 2.190)	0.504
60–79	46			2.329 (1.316, 4.124)	0.004
≥80	33.5			3.730 (1.931, 7.205)	<0.001
Race		7.202	0.066		0.158
Black	34			Reference
White	48			—	0.055
Others	44.5			—	0.673
Unknown	77.5			—	0.031
Diagnosis year		17.289	0.001		0.001
2004–2006	117			Reference
2007–2009	86			0.588 (0.448, 0.773)	0
2010–2012	48			0.707 (0.522, 0.956)	0.025
2013–2015	15			0.527 (0.324, 0.859)	0.01
Marital status		21.099	<0.001		0.029
Married	49			Reference
Single	47			0.851 (0.580, 1.247)	0.407
Divorced/separated	46			1.592 (1.139, 2.224)	0.006
Widowed	47			1.254 (0.865, 1.818)	0.233
SEER stage		195.694	<0.001		<0.001
Localized	48			Reference
Regional	65.5			2.651 (1.989, 3.533)	<0.001
Metastatic	13			10.733 (6.351, 18.141)	<0.001
Surgery		98.593	<0.001		<0.001
Yes	41			Reference
No/unknown	48			0.456 (0.388, 0.534)	<0.001
Median household income		10.754	0.013		0.320
Quartile 1	47			Reference
Quartile 2	45			—	0.413
Quartile 3	47			—	0.453
Quartile 4	55			—	0.853
Registry sites		10.613	0.014		0.002
West	46			Reference
Midwest	50			0.927 (0.639, 1.347)	0.692
South	48			1.620 (1.242, 2.113)	<0.001
Northeast	60			0.923 (0.667, 1.278)	0.631