Research Article
The Influence of Marital Status on the Survival of Patients with Uveal Melanoma
Table 3
Univariate and multivariate analysis for CSS in uveal melanoma patients.
| Variables | Median CCS (month) | Univariate analysis | Multivariate analysis | Log-rank χ2 | value | HR (95% CI) | value |
| Gender | | | | | 0.023 | Male | 47 | 4.164 | 0.041 | Reference | | Female | 50 | | | 0.767 (0.610, 0.965) | | Age at diagnosis | | 21.099 | <0.001 | | <0.001 | <40 | 51.5 | | | Reference | | 40–59 | 57 | | | 1.221 (0.680, 2.190) | 0.504 | 60–79 | 46 | | | 2.329 (1.316, 4.124) | 0.004 | ≥80 | 33.5 | | | 3.730 (1.931, 7.205) | <0.001 | Race | | 7.202 | 0.066 | | 0.158 | Black | 34 | | | Reference | | White | 48 | | | — | 0.055 | Others | 44.5 | | | — | 0.673 | Unknown | 77.5 | | | — | 0.031 | Diagnosis year | | 17.289 | 0.001 | | 0.001 | 2004–2006 | 117 | | | Reference | | 2007–2009 | 86 | | | 0.588 (0.448, 0.773) | 0 | 2010–2012 | 48 | | | 0.707 (0.522, 0.956) | 0.025 | 2013–2015 | 15 | | | 0.527 (0.324, 0.859) | 0.01 | Marital status | | 21.099 | <0.001 | | 0.029 | Married | 49 | | | Reference | | Single | 47 | | | 0.851 (0.580, 1.247) | 0.407 | Divorced/separated | 46 | | | 1.592 (1.139, 2.224) | 0.006 | Widowed | 47 | | | 1.254 (0.865, 1.818) | 0.233 | SEER stage | | 195.694 | <0.001 | | <0.001 | Localized | 48 | | | Reference | | Regional | 65.5 | | | 2.651 (1.989, 3.533) | <0.001 | Metastatic | 13 | | | 10.733 (6.351, 18.141) | <0.001 | Surgery | | 98.593 | <0.001 | | <0.001 | Yes | 41 | | | Reference | | No/unknown | 48 | | | 0.456 (0.388, 0.534) | <0.001 | Median household income | | 10.754 | 0.013 | | 0.320 | Quartile 1 | 47 | | | Reference | | Quartile 2 | 45 | | | — | 0.413 | Quartile 3 | 47 | | | — | 0.453 | Quartile 4 | 55 | | | — | 0.853 | Registry sites | | 10.613 | 0.014 | | 0.002 | West | 46 | | | Reference | | Midwest | 50 | | | 0.927 (0.639, 1.347) | 0.692 | South | 48 | | | 1.620 (1.242, 2.113) | <0.001 | Northeast | 60 | | | 0.923 (0.667, 1.278) | 0.631 |
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