Research Article
Optimization of a Rabbit Dry Eye Model Induced by Topical Instillation of Benzalkonium Chloride
Figure 3
Normalized effect on tear parameters after the instillation of saline solution (control) and 0.2% benzalkonium chloride (BAC) for 5 days. Tear secretion without (a) and with anesthesia (b), tear breakup time (c), and tear osmolarity (d). The instillation of 0.2% BAC decreased tear secretion with anesthesia, tear breakup time, and tear osmolarity compared to the control group, while tear secretion without anesthesia was increased. Values higher and lower than 100% represent an increase or decrease, respectively, compared to their baseline. Statistical comparison was done between both groups. , Student’s t-test for independent samples. , the Mann–Whitney U test.
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