Optimization of a Rabbit Dry Eye Model Induced by Topical Instillation of Benzalkonium Chloride

Table 1

Results of the pilot study on the presence of corneal ulcer, neovascularization, and scarring after the instillation of saline solution (control) and the different concentrations of BAC (0.1%, 0.2%, and 0.3%).

Corneal sign	Group	Number of instillations
		First week		Second week
		5	10	15	20
Ulcer	Control	−	−	−	−
	0.1% BAC	−	−	−	−
	0.2% BAC	−	−	+	+
	0.3% BAC	−	+	+	+
Neovascularization	Control	−	−	−	−
	0.1% BAC	−	−	−	−
	0.2% BAC	−	−	+	+
	0.3% BAC	−	+	+	+
Scarring	Control	−	−	−	−
	0.1% BAC	−	−	−	−
	0.2% BAC	−	−	+	+
	0.3% BAC	−	+	+	+

The positive and negative signs indicate the presence or absence of these signs, respectively.