Three-Decade Evaluation of Cerebrospinal Fluid Pressure in Open-Angle Glaucoma at a Tertiary Care Center
Table 2
Validation of 2007–2019 data.
OAG control
OAG
value
NTG only
value
OHT control
OHT
value
(n = 48)
(n = 29)
(N = 7)
(N = 48)
(N = 17)
Biological sex (M)
27 (56.3%)
17 (58.6%)
1.0000
5 (71.4)
0.69
24 (50%)
8 (47.1%)
1.0000
Ethnicity, n (%)
0.40
1.0000
1.0000
Hispanic or Latino
0 (0.0%)
0 (0.0%)
0 (0.0%)
1 (2.1%)
0 (0.0%)
Not Hispanic or Latino
43 (89.6%)
28 (96.6%)
7 (100.0%)
42 (87.5%)
15 (88.2%)
Unknown
5 (10.4%)
1 (3.4%)
0 (0.0%)
5 (10.4%)
2 (11.8%)
Race, n (%)
0.29
1.0000
0.35
Asian
0 (0.0%)
1 (3.4%)
0 (0.0%)
0 (0.0%)
1 (5.9%)
White
46 (95.8%)
28 (96.6%)
7 (100.0%)
43 (89.6%)
15 (88.2%)
Unknown/not reported
2 (4.2%)
0 (0.0%)
0 (0.0%)
3 (6.3%)
1 (5.9%)
Other
0 (0.0%)
0 (0.0%)
0 (0.0%)
2 (4.2%)
0 (0.0%)
Age in years at LP, mean (SD)
68.2 (8.1)
731 (12.4)
0.04
76.3 (11.4)
0.05
59.0 (13.7)
59.4 (15.4)
0.85
BMI mean (SD)
28.8 (5.5)
26.8 (5.9)
0.17
26.3 (4.4)
0.23
29.6 (7.3)
27.8 (7.2)
0.39
LP indication
<0.01
0.09
0.71
Headache
2 (4.2%)
2 (6.9%)
0 (0.0%)
6 (12.5%)
6 (35.3%)
Peripheral neuropathy
10 (20.8%)
1 (3.4%)
0 (0.0%)
10 (20.8%)
4 (23.5%)
Radiculopathy
5 (10.4%)
2 (6.9%)
0 (0.0%)
4 (8.3%)
1 (5.9%)
IRB-approved research study
12 (25.0%)
13 (44.8%)
6 (85.7%)
10 (20.8%)
2 (11.8%)
Altered mental status
0 (0.0%)
2 (6.9%)
0 (0.0%)
0 (0.0%)
0 (0.0%)
Normal pressure hydrocephalus
0 (0.0%)
2 (6.9%)
1 (14.3%)
0 (0.0%)
0 (0.0%)
Generalized weakness
0 (0.0%)
2 (6.9%)
0 (0.0%)
3 (6.3%)
1 (5.9%)
Stroke
0 (0.0%)
1 (3.4%)
0 (0.0%)
2 (4.2%)
0 (0.0%)
Ataxia
5 (10.4%)
1 (3.4%)
0 (0.0%)
1 (2.1%)
1 (5.9%)
Hearing loss
1 (2.1%)
0 (0.0%)
0 (0.0%)
1 (2.1%)
0 (0.0%)
Pretransplant evaluation
3 (6.3%)
0 (0.0%)
0 (0.0%)
2 (4.2%)
1 (5.9%)
Dementia
6 (12.5%)
1 (3.4%)
0 (0.0%)
8 (16.7%)
1 (5.9%)
Hematological workup
4 (8.3%)
1 (3.4%)
0 (0.0%)
0 (0.0%)
0 (0.0%)
Dizziness
0 (0.0%)
1 (3.4%)
0 (0.0%)
1 (2.1%)
0 (0.0%)
CSF protein Mean (SD)
69.1 (47.0)
63.3 (23.5)
0.74
51.8 (25.6)
52.8 (20.1)
0.63
CSF glucose Mean (SD)
60.9 (17.0)
66.9 (15.7)
0.39
65.2 (27.7)
65.1 (18.9)
0.46
Systolic BP Mean (SD)
128.3 (16.2)
131.0 (18.2)
0.34
123.1 (19.5)
0.71
123.7 (15.1)
127.5 (18.3)
0.51
Diastolic BP Mean (SD)
74.2 (9.6)
72.7 (11.3)
0.52
71.1 (17.7)
0.60
73.8 (9.4)
76.8 (10.2)
0.28
Demographics are similar between cases and controls except for age in the OAG cases and OAG controls. Age was controlled for in all future multivariable analyses. Other patient characteristics from the lumbar puncture visit are similar between cases and controls. Comparison achieved statistical significance ; for BMI in the OAG group.
