Journal of Ophthalmology / 2020 / Article / Tab 2

Research Article

Three-Decade Evaluation of Cerebrospinal Fluid Pressure in Open-Angle Glaucoma at a Tertiary Care Center

Table 2

Validation of 2007–2019 data.

OAG controlOAG valueNTG only valueOHT controlOHT value
(n = 48)(n = 29)(N = 7)(N = 48)(N = 17)

Biological sex (M)27 (56.3%)17 (58.6%)1.00005 (71.4)0.6924 (50%)8 (47.1%)1.0000
Ethnicity, n (%)0.401.00001.0000
 Hispanic or Latino0 (0.0%)0 (0.0%)0 (0.0%)1 (2.1%)0 (0.0%)
 Not Hispanic or Latino43 (89.6%)28 (96.6%)7 (100.0%)42 (87.5%)15 (88.2%)
 Unknown5 (10.4%)1 (3.4%)0 (0.0%)5 (10.4%)2 (11.8%)

Race, n (%)0.291.00000.35
 Asian0 (0.0%)1 (3.4%)0 (0.0%)0 (0.0%)1 (5.9%)
 White46 (95.8%)28 (96.6%)7 (100.0%)43 (89.6%)15 (88.2%)
 Unknown/not reported2 (4.2%)0 (0.0%)0 (0.0%)3 (6.3%)1 (5.9%)
 Other0 (0.0%)0 (0.0%)0 (0.0%)2 (4.2%)0 (0.0%)

Age in years at LP, mean (SD)68.2 (8.1)731 (12.4)0.0476.3 (11.4)0.0559.0 (13.7)59.4 (15.4)0.85
BMI mean (SD)28.8 (5.5)26.8 (5.9)0.1726.3 (4.4)0.2329.6 (7.3)27.8 (7.2)0.39
LP indication<0.010.090.71
 Headache2 (4.2%)2 (6.9%)0 (0.0%)6 (12.5%)6 (35.3%)
 Peripheral neuropathy10 (20.8%)1 (3.4%)0 (0.0%)10 (20.8%)4 (23.5%)
 Radiculopathy5 (10.4%)2 (6.9%)0 (0.0%)4 (8.3%)1 (5.9%)
 IRB-approved research study12 (25.0%)13 (44.8%)6 (85.7%)10 (20.8%)2 (11.8%)
 Altered mental status0 (0.0%)2 (6.9%)0 (0.0%)0 (0.0%)0 (0.0%)
 Normal pressure hydrocephalus0 (0.0%)2 (6.9%)1 (14.3%)0 (0.0%)0 (0.0%)
 Generalized weakness0 (0.0%)2 (6.9%)0 (0.0%)3 (6.3%)1 (5.9%)
 Stroke0 (0.0%)1 (3.4%)0 (0.0%)2 (4.2%)0 (0.0%)
 Ataxia5 (10.4%)1 (3.4%)0 (0.0%)1 (2.1%)1 (5.9%)
 Hearing loss1 (2.1%)0 (0.0%)0 (0.0%)1 (2.1%)0 (0.0%)
 Pretransplant evaluation3 (6.3%)0 (0.0%)0 (0.0%)2 (4.2%)1 (5.9%)
 Dementia6 (12.5%)1 (3.4%)0 (0.0%)8 (16.7%)1 (5.9%)
 Hematological workup4 (8.3%)1 (3.4%)0 (0.0%)0 (0.0%)0 (0.0%)
 Dizziness0 (0.0%)1 (3.4%)0 (0.0%)1 (2.1%)0 (0.0%)

CSF protein Mean (SD)69.1 (47.0)63.3 (23.5)0.7451.8 (25.6)52.8 (20.1)0.63
CSF glucose Mean (SD)60.9 (17.0)66.9 (15.7)0.3965.2 (27.7)65.1 (18.9)0.46
Systolic BP Mean (SD)128.3 (16.2)131.0 (18.2)0.34123.1 (19.5)0.71123.7 (15.1)127.5 (18.3)0.51
Diastolic BP Mean (SD)74.2 (9.6)72.7 (11.3)0.5271.1 (17.7)0.6073.8 (9.4)76.8 (10.2)0.28

Demographics are similar between cases and controls except for age in the OAG cases and OAG controls. Age was controlled for in all future multivariable analyses. Other patient characteristics from the lumbar puncture visit are similar between cases and controls. Comparison achieved statistical significance ; for BMI in the OAG group.

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