Use of iStent as a Standalone Operation in Patients with Open-Angle Glaucoma

Table 1

Characteristics of patients in studies included in meta-analysis.

Author, year	Age (years)	iStent generation	iStent number	Follow-up (months)	Number of eyes	Baseline IOP (mmHg)	End point IOP (mmHg)	Number of baseline medications	Number of end point medications	Reduction in IOP (mmHg)	Reduction in number of medications
Buznego, 2008 [17]	NR	First	1	18	41	21.5 ± 6.9	16.7 ± 6.9	1.6 ± 1.7	0.4 ± 1.7	4.8	1.2
Ahmed et al., 2014 [18]	62.8 ± 12.6	First	2	18	39	22.2 ± 2.0	11.8 ± 2.1	2 ± 0	1 ± 0	10.4	1 ± 0
Fea et al., 2014 [19]	64.5 ± 10.3	Second	2	12	94	21.1 ± 1.7	13.0 ± 2.3	1 ± 0	0.09 ± 0.40	8.1 ± 2.6	0.91 ± 0.40
Voskanyan et al., 2014 [20]	66.4 ± 10.9	Second	2	12	99	22.1 ± 3.3	15.7 ± 3.7	2.21 ± 0.44	NR	6.4	1.78 ± 0.91
Donnenfeld et al., 2015 [21]	66.7 ± 10.0	First	2	36	39	20.6 ± 2.0	15.2 ± 2.1	1 ± 0	NR	5.5 ± 2.7	NR
Katz et al., 2015 [22]	68.1 ± 9.1	First	1	18	38	19.8 ± 1.3	15.6 ± 1.5	1.71 ± 0.61	0.111 ± 0.5	4.2	1.6
	67.8 ± 9.3	First	2	18	41	20.1 ± 1.6	13.8 ± 1.3	1.76 ± 0.54	0.121 ± 0.394	6.3	1.64
	60.9 ± 8.1	First	3	18	40	20.4 ± 1.8	12.1 ± 1.2	1.51 ± 0.69	0.079 ± 0.269	8.3	1.50
Klamann et al., 2015 [23]	61.67 ± 5.15	Second	2	6	17 (POAG)	21.19 ± 2.56	14.19 ± 1.38	2.19 ± 0.91	0.88 ± 0.62	7.0	1.31
	62.76 ± 4.81	Second	2	6	15 (PEX)	23.75 ± 3.28	15.33 ± 1.07	2.33 ± 1.23	1.04 ± 0.30	8.42	1.29
Ferguson et al., 2016 [24]	80.07 ± 8.54	First	1	24	42	20.26 ± 6.00	13.62 ± 4.55	1.95 ± 1.01	1.33 ± 1.22	6.64	0.62
Lindstrom et al., 2016 [25]	65.3 ± 9.0	Second	2	18	57	19.5 ± 1.5	14.4 ± 2.1	1 ± 0	0.02 ± 0.13	5.1	0.98
Vold et al., 2016 [26]	64.5 ± 11.1	First	2	36	54	25.5 ± 2.5	14.6 ± 2.4	0 ± 0	0.21 ± 0.54	10.9	0.79
Berdahl et al., 2017 [27]	64.7 ± 9.6	Second	2	18	53	19.7 ± 1.5	12.9 ± 2.1	2 ± 0	1 ± 0	6.8	1 ± 0
Chang et al., 2017 [28]	62.8 ± 12.6	First	2	36	39	22.4 ± 2.3	14.0 ± 2.6	2 ± 0	1 ± 0	8.4	1 ± 0
Pahlitzsch et al., 2017 [29]	68.6 ± 16.4	First	2	6	20	21.3	16.0	2.45	2.5	5.3	Increase 0.05
Shiba et al., 2017 [30]	64.6 ± 10.7	First	2	6	10	22.0 ± 3.0	16.9 ± 3.6	NR	NR	5.1	NR
Katz et al., 2018 [31]	68.1 ± 9.1	First	1	42	38	19.8 ± 1.3	15.0 ± 2.8	1.71 ± 0.61	0.55 ± 0.50	4.8	1.16
	68.1 ± 9.1	First	2	42	41	20.1 ± 1.6	15.7 ± 1.0	1.76 ± 0.54	0.105 ± 0.307	4.4	1.66
	68.1 ± 9.1	First	3	42	40	20.4 ± 1.8	14.8 ± 1.3	1.53 ± 0.69	0.08 ± 0.27	5.6	1.45
Ahmed et al., 2019 [32]	66.5 ± 9.5	First	2	12	77	19.1 ± 3.6	18.1 ± 3.7	2.7 ± 0.8	1.69 ± 1.37	1.0	1.01
Hengerer et al., 2019 [33]	71.3 ± 10.5	Second	2	36	44	25.3 ± 6.0	14.6 ± 2.0	2.98 ± 0.88	0.55 ± 0.79	10.7	2.43

PEX = pseudoexfoliation glaucoma.