Comparison between Cryopreserved and Dehydrated Human Amniotic Membrane Graft in Treating Challenging Cases with Macular Hole and Macular Hole Retinal Detachment

Figure 3

Preoperative fundus photograph (a) and optical coherence tomography (OCT) image (b) of a persistent macular hole (MH) for 26 years in a 59-year-old female. She had received vitrectomy with membrane peeling 2 times for macular retinal detachment before. The size of the MH was about 1250 μm. Macular hole sealed after transplantation of a cryopreserved human amniotic membrane (hAM) graft. One-month postoperative fundus photograph (c) and OCT (d) showed the hAM graft in place connecting 2 ends of MH with partial hAM at retina surface. An extramacular hole (e) (arrow) with retinal detachment (f) (arrowhead) developed 2 months after the surgery. The extramacular hole was sealed, and retina re-attached with dehydrated hAM transplantation in the second surgery in oil phase (g)–(i). OCT (i) showed the extramacular hole was sealed with the hAM graft adhered to retinal pigment epithelium (arrowhead).