Journal of Ophthalmology

Research Article

Glutathione S-Transferase Omega-2 and Transforming Growth Factor-β1 Polymorphisms in Iranian Glaucoma Patients

Table 3

The frequencies of GSTO2 (142N > D) and TGF-β1 (869T > C) genotypes in POAG, CACG patients, and control groups.


Locus	Genotype	POAG, N (%)	CACG, N (%)	Control, N (%)	OR₁	OR₂	95% CI₁	95% CI₂

GSTo2 (N142D)	DD	16 (28.6)	12 (27.3)	38 (35.8)	0.71	0.54	0.35–1.44	0.25–1.14
	ND	33 (58.9)	29 (65.9)	51 (48.1)	1.55	2.08	0.80–2.98	1.00–4.33
	NN	7 (12.5)	3 (6.8)	17 (16.0)	0.75	0.38	0.29–1.93	0.11–1.38

TGF-β (T869C)	TT	12 (21.4)	13 (29.5)	29 (27.4)	0.72	1.11	0.34–1.56	0.51–2.42
	CT	25 (44.6)	18 (40.9)	54 (50.9)	0.78	0.67	0.40–1.42	0.33–1.36
	CC	19 (33.9)	13 (29.5)	23 (21.7)	1.85	1.51	0.90–3.81	0.68–3.35

N: number, OR: odds ratio, CI: confidence interval. OR₁and OR₂: odds of each genotype to reference in POAG and CACG patient groups/the odds of each genotype to reference for the control group. value< 0.05. CI₁and CI₂: confidence interval of OR₁ and OR₂ in POAG and CACG patients groups.