Glutathione S-Transferase Omega-2 and Transforming Growth Factor-β1 Polymorphisms in Iranian Glaucoma Patients

Table 4

The frequencies of GSTO2 (142N > D) and TGF-β1 (869T > C) genotypes in patients with glaucoma and controls after grouping according to gender.

Locus	Genotype	Patients, male, N (%)	Control, male, N (%)	Patients, female, N (%)	Control, female, N (%)	( value)	OR1	95% CI 1	( value)	OR2	95% CI 2
GSTO2 (142N > D)	DD	20 (33.33)	23 (46)	8 (20)	15 (26.78)	4.77 (0.09)	0.59	0.27–1.27	1.06 (0.59)	0.68	0.26–1.81
	ND	35 (58.33)	19 (38)	27 (67.5)	32 (57.14)		2.28	1.06–4.92		1.56	0.67–3.63
	NN	5 (8.33)	8 (16)	5 (12.5)	9 (16.07)		0.48	0.15–1.56		0.75	0.23–2.42
TGF-β1 (869T > C)	TT	14 (23.33)	10 (20)	11 (27.5)	13 (23.21)	0.79 (0.67)	1.22	0.49–3.04	5.06 (0.08)	1.25	0.49–3.18
	CT	28 (46.66)	21 (42)	15 (37.5)	33 (58.92)		1.21	0.57–2.58		0.42	0.18–0.96
	CC	18 (30)	19 (38)	14 (35)	10 (17.85)		0.70	0.32–1.55		2.48	0.96–6.36

and are the associations between genotype distribution and patients/control groups in male and female. OR₁ and OR₂ are the odds of each genotype to reference in the patients group/the odds of each genotype to reference for the control group in male and female. CI₁ and CI₂ are the confidence interval of OR₁ and OR₂ in each gender group. value < 0.05.