Comparison of Patient Outcomes following Implantation of Trifocal and Extended Depth of Focus Intraocular Lenses: A Systematic Review and Meta-Analysis

Table 1

Characteristics of the included studies (n = 13).

Study	Location	Design	EDOF			Trifocal			Follow-up duration (months)
			IOL types	N (patients/eyes)	Age (mean ± SD, years)	IOL types	N (patients/eyes)	Age (mean ± SD, years)
Monaco et al. 2017 [31]	Italy	RCT	TECNIS Symfony	20/40	67.0 ± 8.5	AcrySof IQ PanOptix	20/40	66.0 ± 5.5	4
Ruiz-Mesa et al. 2017 [18]	Spain	NRCS	TECNIS Symfony	20/40	59.5 ± 8.9	FineVision Micro F	20/40	54.5 ± 7.2	12
Cochener et al. 2018 [30]	France	RCT	TECNIS Symfony	20/40	69.2 ± 8.4	AcrySof IQ PanOptix	20/40	62.5 ± 4.6	6
						FineVision Micro F	20/40	62.5 ± 4.6
Mencucci et al. 2018 [34]	Italy	NRCS	TECNIS Symfony	20/40	68.9 ± 4.8	AcrySof IQ PanOptix	20/40	70.1 ± 4.8	3
						AT LISA tri 839MP	20/40	71.6 ± 4.4
Ruiz-Mesa et al. 2018 [35]	Spain	NRCS	TECNIS Symfony	14/28	63.1 ± 10.0	AcrySof IQ PanOptix	20/40	63.8 ± 8.1	9∼29
Escandon-Garcia et al. 2018 [36]	Portugal	NRCS	TECNIS Symfony	15/30	63.5 ± 9.4	AcrySof IQ PanOptix	7/14	62.3 ± 9.0	1∼3
						FineVision Pod F	23/46	62.6 ± 8.0
de Medeiros et al. 2019 [37]	Brazil	NRCS	TECNIS Symfony	14/28	NA	AcrySof IQ PanOptix	13/26	NA	6∼12
Singh et al. 2019 [38]	India	NRCS	TECNIS Symfony	40/80	69.1 ± 6.1	FineVision Micro F	40/80	66.1 ± 5.1	6
Rodov et al. 2019 [39]	Israel	NRCS	TECNIS Symfony	50/100	67.21 ± 9.83	FineVision Micro F	50/100	67.01 ± 6.73	1∼22
Böhm et al. [40]	Germany	NRCS	TECNIS Symfony	26/52	69.23 ± 8.17	AT LISA tri 839MP	27/54	63.51 ± 7.94	3
Gil et al. 2020 [33]	Spain	RCT	TECNIS Symfony	20/20	68.2 ± 6.2	AT LISA tri 839MP	19/19	68.7 ± 10.3	6
Lin et al. 2019 [41]	China	NRCS	TECNIS Symfony	26/26	NA	AT LISA tri 839MP	24/24	NA	1
Webers et al. 2020 [32]	Netherlands	RCT	TECNIS Symfony	14/28	67.57 ± 12.21	AT LISA tri 839MP	13/26	70.38 ± 6.08	3

IOL, intraocular lens; RCT, randomized controlled trial; NRCS, nonrandomized controlled study; EDOF, extended depth-of-focus