Review Article

Surgical Management of Paediatric Aphakia in the Absence of Sufficient Capsular Support

Table 1

The most important studies of scleral-sutured IOLs in paediatric population.

StudyDesignNumber of patients (eyes)Key results

Sharpe et al. (1996)Retrospective outcomes of scleral-sutured PCIOLs7 (7)(1) VA improvement in six of seven patients (average improvement of 4 lines)
(2) Complications: scleral fixation suture exposure (n = 1), lens decentration (n = 1), and lens tilt (n = 1)

Lam et al. (1998)Retrospective safety and efficacy of scleral fixated IOLs3 (6)(1) Good visual improvement
(2) Stable and well-positioned PCIOL after surgery in all eyes
(3) Complications: asymptomatic pupillary IOL capture in 3 eyes

Kumar et al. (1999)Prospective case series evaluation of scleral fixated IOL implantation11 (11)(1) Postoperative BCVA: stable in 54.5%, improved by more than 1 Snellen line 27.2% and decreased by more than 1 Snellen line in 18.1%
(2) Complications: suture erosion through the conjunctiva in 18.18%, marked postoperative anterior chamber reaction in 18.18%, IOL decentration in 9.09%, glaucoma in 9.09%, and cystoid macular edema in 9.09%

Zetterström et al. (1999)Retrospective long-term outcomes of scleral-sutured PCIOLs13 (21)(1) Postoperative BCVA: stable or improved
(2) Complications: posterior synechiae (n = 4), cells on the IOL surface (n = 4), and IOL subluxation (n = 2); no visual axis opacification, secondary glaucoma, or retinal complication was recorded

Vadalà et al. (2000)Retrospective results of scleral fixated IOLs3 (5)(1) Postoperative VA: 20/20 to 20/40
(2) Complications: IOL dislocation (n = 1) and posterior capsular opacification (n = 3)

Jacobi et al. (2002)Prospective evaluation of transscleral fixated IOLs26 (26)(1) Postoperatively, BCVA within one Snellen line was achieved by more than 80% of the patients
(2) Complications: IOP increase in 11.5%, marked anterior chamber reaction in 15.4%, IOL decentration in 19.2%, and suture erosion through the conjunctiva in 7.4%

Sewelam et al. (2001)Retrospective haptic position evaluation of transscleral fixated PC IOLs using UBM20 (20)IOL haptics located in the sulcus (55.0%), anterior to the sulcus (27.5%), and posterior to the sulcus (17.5%)

Ozmen et al. (2002)Retrospective assessment of the visual outcome and complications of transscleral fixated IOLs18 (21)(1) Visual improvement of more than 2 Snellen lines in 9 eyes (42.8%)
(2) Complications: the most severe were concurrent endophthalmitis and retinal detachment (n = 1); the most common were pupillary distortion, transient pupillary membrane, pupillary capture, and strabismus and anterior uveitis

Bardorf et al. (2004)Retrospective long-term results of transscleral-sutured IOLs(1) Postoperative VA: improved in 70%; in 51% improved by two lines or more; no patient suffered visual acuity loss
(2) Complications: small hyphemas (7%), vitreous hemorrhage (5%), ocular hypertension or hypotony (5%) and iris capture of the IOL optic (5%); no retinal detachment or other retinal complications were reported

Buckley (2007)Retrospective long-term outcomes of transscleral-sutured PCIOLs26 (33)(1) Postoperative VA: significantly improved
(2) Complications: intraoperative and immediate postoperative minimal and not sight-threatening; IOL subluxation due to spontaneous 10-0 polypropylene suture breakage (n = 3) at 3.5, 8, and 9 years after surgery; 10 similar cases by a survey of paediatric ophthalmologists (mean, 5 years after surgery)

Asadi and Kheirkhah (2008)Case series long-term results of transscleral fixated PCIOLs23 (25)(1) Postoperative BCVA: improved in 48% by >1 Snellen line; the main cause of reduced vision was corneal and retinal pathologies and amblyopia
(2) Complications: transient intraocular hemorrhage (52%), transient choroidal effusion (8%), late endophthalmitis (4%), retinal detachment (4%), and late IOL dislocation due to breakage of polypropylene sutures after 7 to 10 years (24%)

Olsen and Pribila (2011)Retrospective sulcus fixated, sutured PCIOL using endoscopic guidance during PPV20 (21)(1) Most patients had visual function improvement
(2) Complications: suture breakage (n = 2) due to repeat trauma
(3) Advantages: excellent visualization and haptic localization, optimal lens centration, buried knots, broad scleral imbrication, and minimal vitreous- and hemorrhage-related complications
(4) Disadvantages: learning curve, increased operative time, long-term suture stability issues, and limited availability of intraocular endoscopes

Burcu et al. (2014)Retrospective evaluation of the outcomes of scleral fixated PCIOLs14 (24)Median postoperative BCVA: 0.2 (min: hand motion; max: 0.8) in decimal notation ; BCVA improved at least one Snellen line or remained unchanged in all eyes

PCIOL: posterior chamber-intraocular lens, VA: visual acuity, BCVA: best corrected visual acuity, IOP: intraocular pressure, UBM: ultrasound biomicroscopy, and PPV: pars-plana vitrectomy.