Characterizing Flow and Structure of Diabetic Retinal Neovascularization after Intravitreal Anti-VEGF Using Optical Coherence Tomography Angiography: A Pilot Study

Figure 2

(a) Changes of neovascularization- (NV-) size measurements relative to baseline after the initial treatment block of three to four intravitreal anti-VEGF injections, and at the last follow-up. En face structural area (NV-structure) decreased by median 15% (range −28%–100%) and remained decreased by median 6% (−196%–100%). En face flow area (NV-angio) decreased by median 48% (range 10–100%) and remained by median 34% less than baseline (−13%–100%). The graph shows the reduction of NV size is more prominent in the angio than the structural en face OCTA image. (b) En face flow density (FD) measurements within the structural neovascularization (NV-area (FD-structure) and the flow NV-area (FD-angio)) at baseline, after the initial treatment block of three to four intravitreal anti-VEGF injections, and at the last follow-up: FD-structure started at median 64% (range 41–82%), decreased to median 32% (0–73%), and remained at median 32% (0–70%). FD-angio started at median 71% (range 48–89%), decreased to median 51% (0–84%), and remained at median 54% (0–75%). The graph shows that the difference in flow density between baseline, after treatment, and with apparently quiescent diabetic retinal neovascularization is more pronounced within the structural than the angio area of a NV.

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