Significance of Hyperreflective Foci as an Optical Coherence Tomography Biomarker in Retinal Diseases: Characterization and Clinical Implications

Figure 1

Spectral-domain optical coherence tomography B-scan showing the morphological differences between the inflammatory hyperreflective foci (Inset I is characterized by small size (≤30 μm), the absence of posterior shadowing, inner and outer retinal location, and the reflectivity similar to the retinal nerve fiber layer (light blue arrows), and other subtypes of hyperreflective material (Inset II) such as retinal exudates are characterized by preferential location in the outer retinal layers, size > 30 μm, the presence of posterior shadowing, and reflectivity similar to the retinal pigment epithelium (yellow arrowheads)).