Fundus Autofluorescence and Optical Coherence Tomography Characteristics in Different Stages of Central Serous Chorioretinopathy

Table 2

Comparisons of the FAF and OCT findings between early-acute, subacute, and early-chronic CSC patients.

	Acute CSC (n = 8)	Early-chronic CSC (n = 34)	Late-chronic CSC (n = 27)	value
Age (years)	40 ± 14.6	52.6 ± 8.6	54.2 ± 10.9	0.028^b; 0.05^c3
Visual acuity (LogMAR)	0.057 ± 0.27	0.111 ± 0.26	0.38 ± 0.39	0.034^b; 0.033^c3
Choroidal layer thickness (μm)	364 ± 138.9	319 ± 47.7	337 ± 54.6	0.548 ^b
FAF findings at leakage site
Discrete hypo-FAF spot	8 (100%)	21 (61.8%)	14 (51.9%)	0.044^a
Indistinct pattern at leakage site	0	13 (38.2%)	13 (48.1%)
Background FAF findings
Hyper-FAF	8 (100%)	28 (82.4%)	17 (63%)	0.020^a
Hypo-FAF	0	0	6 (22.2%)
Mixed-pattern AF	0	6 (17.7%)	4 14.8%)
OCT findings-RPE abnormalities
Type 1: semicircular peaked PED	4 (50%)	11 (32.4%)	2 (7.4%)	0.025^a
Type 2: low-lying PEDs	4 (50%)	8 (23.5%)	5 (18.5%)
Type 3: flat irregular PEDs		11 (32.3%)	9 (33.3%)
Type 4: RPE irregularity without definite PED		4 (11.8%)	11 (40.7%)
Height of PEDs (μm)	133.3 ± 57.4	70.0 ± 5.62	72.1 ± 17.5	0.329 ^c1; 0.028^c2
Width of PEDs (μm)	367.5 ± 139.2	499.3.0 ± 182.6	1297.9 ± 728.8	0.004^b
Abnormalities of outer retina
Length of the photoreceptor (IS/OS) layer (μm)	79.0 ± 13.3	72.8 ± 29.5	55.2 ± 19.9	0.017^b
Presence of elongation or thinning of OS photoreceptor
Elongation	1	2	1	0.002^a
Normal thickness	5	6	6
Thinning	0	1	14
Presence of subretinal precipitates	1	1	11	0.001^a
Presence of fibrinous exudates	6	9	22	0.001^d

^aFisher’s exact test. ^bANOVA test (analysis of variance test). ^c1t-test comparing acute and early-chronic groups. ^c2t-test comparing early-chronic and late-chronic groups. ^c3t-test comparing acute and late-chronic groups. ^dChi-Square test. , value less than 0.005, with statistically significant result observed.