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| First author | Year | Country | Study design | Group | Number of eyes | Mean age (year) | Follow-up (months) | UVA irradiation dose (mW/cm2) time (min) | UVA cumulative dose (J/cm2) | Riboflavin concentration (%) | Riboflavin before irradiation | Riboflavin during irradiation |
|
| Akbar [13] | 2017 | Arabia | Non-RCT | SCXL
TECXL | 32
32 | 24.81
24.47 | 18 | 3/30
3/30 | 5.4
5.4 | 0.1
0.25 | With HPMC every 2 min for 20 min
With BAC and HPMC one drop every 5s till corneal thickness reached 400u | Every 2 min
Every 2 min |
| Bikbova [15] | 2016 | Russia | RCT | SCXL
TECXL | 73
76 | 30.00
28.00 | 24 | 3/30
3/30 | 5.4
5.4 | 0.1
0.1 | With 20% dextran for 30 min
With iontophoresis for 10 min | Every 2 min
Every 2 min |
| Cifariello [14] | 2018 | Italy | RCT | SCXL
TECXL | 20
20 | 24.00
31.00 | 24 | 3/30
3/30 | 5.4
5.4 | 0.1
0.1 | With 20% dextran every 2 min for 30 min
With ricrolin TE every 5 min for 30 min | Every 2 min
NR |
| Jouve [20] | 2017 | France | Non-RCT | SCXL
TECXL | 40
40 | 26.2
26.2 | 24 | 3/30
10/9 | 54.
5.4 | 0.1
0.1 | With 20% dextran every 2 min for 20 min
With iontophoresis (ricrolin+) for 5 min | Every 5 min
— |
| Kocak [21] | 2014 | Turkey | Non-RCT | SCXL
TECXL | 19
17 | 27.16
27.35 | 12 | 3/30
3/30 | 5.4
5.4 | 0.1
0.1 | With 20% dextran every 2 min for 30 min
With ricrolin TE every 2 min for 30 min | Every 2 min
Every 2 min |
| Lombardo a [22] | 2016 | Italy | RCT | SCXL
TECXL | 12
22 | 31.05
29.4 | 6 | 3/30
10/9 | 5.4
5.4 | 0.1
0.1 | With 20% dextran every 3 min for 30 min
With iontophoresis (ricrolin+) for 5 min | Every 3 min
— |
| Lombardo b [23] | 2017 | Italy | RCT | SCXL
TECXL | 12
22 | 31.05
29.4 | 12 | 3/30
10/9 | 5.4
5.4 | 0.1
0.1 | With 20% dextran every 3 min for 30 min
With iontophoresis (ricrolin+) for 5 min | Every 3 min
— |
| Lombardo c [24] | 2019 | Italy | RCT | SCXL
TECXL | 12
22 | 31.05
29.4 | 24 | 3/30
10/9 | 5.4
5.4 | 0.1
0.1 | With 20% dextran every 3 min for 30 min
With iontophoresis (ricrolin+) for 5 min | Every 3 min
— |
| Madeira [25] | 2019 | Portugal | Non-RCT | SCXL
TECXl | 10
16 | 18.69
21.90 | 12 | 3/30
6/15 | 5.4
5.4 | 0.1 | 0.1% riboflavin preparation every 2 minutes for 30 minutes
0.25% TE riboflavin preparation every 2 minutes for 20 minutes | Every 5 min
Every 5 min |
| Mastropasqua [26] | 2013 | Italy | RCT | SCXL
TECXL | 20
20 | 23.00
23.00 | 12 | 3/30
3/30 | 5.4
5.4 | 0.1
0.1 | With 20% dextran every 3 min for 15 min
With 20% dextran every 3-5 min for 30 min | Every 3 min
Every 3 min |
| Nawaz [27] | 2015 | India | RCT | SCXL
TECXl | 20
20 | 23.95
22.35 | 6 | 3/30
3/30 | 5.4
5.4 | 0.1
0.1 | With 20% dextran every 3–5 min for 30 min
With 20% dextran every 3–5 min for 30 min | Every 3–5 min
Every 3–5 min |
| Rossi [28] | 2015 | Italy | RCT | SCXL
TECXL | 10
10 | 30.40
28.00 | 12 | 3/30
3/30 | 5.4
5.4 | 0.1
0.1 | With 20% dextran every 2 min for 30 min
With ricrolin TE every 5 min for 30 min | Every 2 min
Every 5 min |
| Rossi a [29] | 2018 | Italy | RCT | SCXL
TECXl | 10
10 | 30.40
27.20 | 12 | 3/30
3/30 | 5.4
5.4 | 0.1
0.1 | With 20% dextran every 2 min for 30 min
With ricrolin TE every 5 min for 30 min | Every 2 min
Every 5 min |
| Rossi b [29] | 2018 | Italy | RCT | SCXL
TECXl | 10
10 | 30.40
28.00 | 12 | 3/30
10/10 | 5.4
NR | 0.1
0.1 | With 20% dextran every 2 min for 30 min
With iontophoresis (ricrolin+) for 5 min | Every 2 min
Every 2 min |
| Soeters [18] | 2015 | Netherlands | RCT | SCXL
TECXL | 26
35 | 25.90
26.90 | 12 | 3/30
3/30 | 5.4
5.4 | 0.1
0.1 | With 20% dextran every 2 min for 30 min
With ricrolin TE every for 30 min | Every 5 min
Every 5 min |
| Stojanovic [30] | 2014 | Norway | RCT | SCXL
TECXl | 20
20 | 29.5
29.5 | 12 | 3/30
3/30 | 5.4
5.4 | 0.5
0.5 | Vitamin B2 applied alternating every 30 sec
BAC and vitamin B2 applied alternating every 30 sec | —
— |
| Vinciguerra [31] | 2016 | Italy | Non-RCT | SCXL
TECXl | 20
20 | 28.2
27.8 | 12 | 3/30
10/9 | 5.4
5.4 | 0.1
0.1 | With 20% dextran every 1 min for 30 min
With iontophoresis (ricrolin+) for 5 min | NR
NR |
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