Journal of Ophthalmology

Journal of Ophthalmology / 2021 / Article

Review Article | Open Access

Volume 2021 |Article ID 6686700 |

Ángel López-Vázquez, Inés Contreras, Sergio Martin-Prieto, Ángel López-Castro, "Weight of Different Intraocular Lenses: Evaluation of Toricity, Focality, Design, and Material", Journal of Ophthalmology, vol. 2021, Article ID 6686700, 5 pages, 2021.

Weight of Different Intraocular Lenses: Evaluation of Toricity, Focality, Design, and Material

Academic Editor: Alessandro Meduri
Received28 Oct 2020
Revised12 Apr 2021
Accepted15 Apr 2021
Published21 Apr 2021


Purpose. To evaluate the weight of intraocular lenses (IOLs) depending on their material, dioptric power, toricity, focality, and haptic design. Methods. Twenty-eight different IOL models from nine different medical companies (a total of 38 IOLs) and 1 capsular tension ring (CTR) were evaluated. IOLs were weighed using a precision scale, in hydrated conditions, as an approximation to their intraocular status. Results. Hydrophilic IOLs were heavier than hydrophobic lenses (). Regarding toricity, no statistical differences were found comparing toric to non-toric models (). Likewise, no differences were found between multifocal IOLs and monofocal IOLs (). Dioptric power did not affect IOL weight: IOLs of <15DP had similar weights to those of ≥15D and IOLs of ≥24D had similar weights to those of <24 D ( and , respectively). Plate-design IOLs were significantly heavier than 1-piece C-loop (), 3-piece C-loop (), and 4-haptic lenses (). Conclusions. Of the characteristics analyzed that might influence IOL weight, lenses with hydrophilic material and plate-haptic design were found to be heavier. Toricity, focality, and dioptric power had no influence on IOL weight.

1. Introduction

Late in-the-bag intraocular lens (IOL) dislocation is a well-known, serious complication derived from cataract surgery. Although an exact rate has not yet been determined, a cumulative incidence of 0.1% after 10 years, 0.2% after 15 years, and 1.7% after 25 years has been reported [1], and this incidence seems to be increasing [13]. The proposed mechanism for dislocation is zonular insufficiency, which might be due to several factors, such as pseudoexfoliation syndrome, capsular contraction syndrome, axial myopia, previous vitreoretinal surgery, and trauma [27].

To the best of our knowledge, the only study on intraocular lens (IOL) weights dates back to 1977, when IOL technology was far different from that currently available [8]. IOLs are available in four types of optic material: polymethylmethacrylate (PMMA), hydrophilic acrylic, hydrophobic acrylic, and hydrophobic silicone. Hydrophobic acrylic IOLs are probably the most implanted type worldwide. Each material has advantages and disadvantages, such as different rates of posterior capsule opacification or resistance to Nd : YAG laser impacts [9]. Regarding the design of the lens, there is a wide variety available. However, 1-piece C-loop, 3-piece C-loop, and plate-design IOLs are the most frequently implanted. With the arrival of toric and multifocal IOLs, not only material or design has to be taken into account, but also the IOL’s refractive properties.

Evaluating the influence of the type of lens on the risk of in-the-bag dislocation is very difficult, as it is nearly impossible to ascertain the lenses implanted in a given population, and even when there is a dislocation requiring surgery, the type of lens is difficult to determine and is often not recorded. Plate-haptic, silicone IOLs seem to produce more capsular shrinkage, one of the risk factors for dislocation; however, there have been reports of IOL dislocations for almost all IOL models [4, 7, 1012]. Since the IOL-bag complex dislocates inferiorly in up to 90% of cases [4, 7], we believe gravity and IOL weight might influence late in-the-bag dislocation. Therefore, it would be of interest to evaluate the weight of IOLs, made from different materials and with several designs.

The main purpose of this study was to assess IOL weights depending on their optic material, dioptric power, toricity, focality, and haptic design.

2. Methods

Twenty-eight different IOL models from nine medical companies and one PMMA capsular tension ring (CTR) were studied. They were weighed using a precision scale (Professional digital mini scale TL-series, Homgeek Incorporation, UK, precision ± 0,001 grams), in hydrated conditions (Figure 1).

To simulate intraocular hydrated conditions, hydrophobic lenses and the CTR ring were immersed in 0.9% sodium chloride (B. Braun Medical AG, Melsungen, Germany) for 60 minutes. They were then weighed after drawing them out from the solution, once surface liquid surplus was removed. Hydrophilic IOLs were weighed after extraction from their package once spare conservation solution was eliminated (Figure 2). All measurements and manipulation were performed by the same blind observer (M-P, S).

Variables recorded for each IOL were dioptric spherical equivalent power (D), hydrated weight (mg), optic material, mono vs multifocality, toricity and design (1-piece C-loop, 3-piece, plate, or 4-haptic design).

2.1. Statistical Analysis

Descriptive statistics were calculated for all variables of interest. Mean values and standard deviations were independently calculated for all variables. The Kolmogórov–Smirnov and Shapiro–Wilk tests confirmed all numerical variables followed a normal distribution. Student’s t-test was used with all variables except for design, on which ANOVA test was performed. Significance was set at . The SPSS software version (International Business Machines Corp, Armonk, NY, USA) was used for all statistical analysis.

3. Results

A total of 38 IOLs and one CTR were included in this study. Table 1 records the weight and characteristics of each IOL included, and Table 2 shows average values according to the different characteristics evaluated.

CompanyModelSe (D)Hydrated weight (Mg)HydrophobicFocalityToricDesign

ZeissCT LUCIA 211P9.5015YesMonoNoCL
ZeissCT LUCIA 611P2819YesMonoNoCL
Aaren scientificAARIS22.5020YesMonoNoCL
ZeissCT SPHERIS 2042132NoMonoNoP
ZeissCT ASPHINA 409 MP2231NoMonoNoP
ZeissCT ASPHINA 4042030NoMonoNoP
TopconLS313 T310.529NoMonoYesP
ZeissAT LISA 839 MP12.526NoMultiNoP
ZeissAT LISA 939 MP21.533NoMultiNoP
Medical mixMICRO +1231725NoMonoNo4H
Medical mixMICRO +A12325.526NoMonoNo4H
Medical mixMICROPURE 12327.518NoMonoNo4H
Medical mixMICROPURE 12312.516NoMonoNo4H
Medical mixFINEVISION PO1523NoMultiNo4H
Medical mixANKORIS TORIC20.2524NoMonoYes4H
Medical mixANKORIS TORIC24.7525NoMonoYes4H
Freedom ringCTR 13-110<1

Mono, monofocal; Multi, multifocal; CL, C-loop; 4H, four haptics; P, plate; 3P, 3-piece.

GroupnAverage weight (mg)Standard deviation

<15 D722.297.06
≥15 D3122.776.30
≥24 D723.867.24
<24 D3122.426.23

The comparison between groups showed statistically significant differences regarding optic material and plate-haptic design vs other designs. The difference was higher when comparing hydrophilic versus hydrophobic lenses. Hydrophylic lenses were heavier (27.24 mg ± 4.73) compared to hydrophobic ones (17.06 mg ± 2.11), . Regarding IOL design, plate-haptic design IOLs were heavier than 1-piece C-loop and 3-piece IOLs () and also heavier than 4-haptic design IOLs (). No statistically significant differences were found between C-loop and 4-haptic IOLs.

Although multifocal IOLs were slightly heavier than monofocal IOLs, the difference was not statistically significant (26.2 mg ± 7.09 vs 22.15 mg ± 6.16, ). There was also a trend for higher weights in toric lenses compared to their spherical counterparts, although again, the difference was not statistically significant (26.0 mg ± 7.09 vs 21.8 mg ± 5.96, ). Regarding IOL power, no significant differences were detected. IOLs with spherical equivalent ≥15D were not heavier or lighter than the group of <15D (22.77 mg ± 6.30 vs 22.29 mg ± 7.06, ), and the same was true for IOLs ≥24D compared to those <24D (23.86 mg ± 7.24 vs 22.42 mg ± 6.23, ).

4. Discussion

Late in-the-bag IOL dislocation is a well-known complication of cataract surgery. Of the factors which play a role in its development, most are inherent to the eye or its past medical history and thus unmodifiable: pseudoexfoliation syndrome, axial myopia, previous vitreoretinal surgery, etc [27]. These factors influencing the zonule’s resistance have been widely studied; however, the influence of the characteristics of the IOL implanted remains unclear.

Capsular contraction syndrome derives from epithelial anterior lens cells, also known as A cells, found in the internal aspect of the anterior capsule [13]. These cells undergo a myofibroblastic differentiation when they come into contact with the IOL surface. Patients with capsular contraction syndrome are at risk of developing zonular weakness and therefore late IOL dislocation. Risk factors for developing capsular contraction syndrome are small diameter capsulorhexis, zonular weakness, chronic intraocular inflammation, pseudoexfoliation syndrome, retinitis pigmentosa, advanced age, diabetes mellitus, Behçet’s syndrome, and high myopia [14]. Given that surgeons can choose the IOL to be implanted and knowing that IOL material and design have been reported as two factors influencing capsular contraction syndrome, many authors have studied their implications. It has been reported that silicone and hydrogel IOLs are associated with greater capsular contraction than acrylic models [15, 16]. As regards acrylic IOLs, hydrophilic optics have been shown to lead more frequently to capsular contraction than hydrophobic optics [15, 17]. Plate-haptic IOLs are also more frequently associated with contraction of the anterior capsule compared to other designs [17, 18]. However, all types of IOL, regardless of material or design, can dislocate over time [4, 7, 1012]. Even though the implantation of a CTR is recommended when zonular insufficiency is suspected, as it distributes zonular tension [19, 20], in-the-bag IOL + CTR subluxation has also been frequently reported [21, 22].

As mentioned above, over 90% of late in-the-bag subluxations are inferior [7, 23], with other dislocation sites being exceptional. Therefore, we suggest that IOL weight may play a role in its pathogenesis. To our knowledge, the only report on IOL weight dates back to the 1970s, analyzing IOLs that have little in common with current IOL technology. Phacoemulsification was not performed in those days when PMMA lenses were the only available option and were implanted in many cases outside the capsular bag [8].

We found that acrylic hydrophilic IOLs were heavier than hydrophobic IOLs. Furthermore, plate-design IOLs were also significantly heavier than other designs. Toricity, focality, or IOL power does not seem to affect IOL weight. Similarly, no differences were found between the other designs included in this study (1- or 3-piece C-loop or 4-haptic).

Our study suggests that certain IOLs characteristics should be considered in patients at risk of late in-the-bag dislocation. Given that hydrophilic IOLs are significantly heavier and lead to greater shrinkage of the anterior capsule [15, 16], we propose hydrophilic IOLs should be avoided in patients with high axial myopia, pseudoexfoliation syndrome, or other risk factors if other options are available. Similarly, as plate-haptic designs were found to be significantly heavier than other designs and produce more often capsular contraction syndromes [15, 16], they should also be avoided in patients with zonular weakness. Since no differences were found when comparing mono to multifocality, toricity or non-toricity, and IOL power, it seems no precautions are necessary when considering the implantation of these lenses.

The benefits of the implantation of a CTR remain controversial. Despite having been proven to distribute zonular tension and prevent anterior capsular shrinkage [17, 18], CTR implantation can also cause an extra trauma during surgery in up to 10% of patients, especially if not adequately inserted [22]. Our study can add that if weight truly matters in intraocular implants, the extra weight of a CTR should not worry surgeons since a PMMA 11–13 mm standard CTR weighs less than 1 mg in hydrated conditions.

In conclusion, acrylic hydrophilic IOLs are significantly heavier than acrylic hydrophobic IOLs and so are plate-design IOLs compared to other designs. Knowing most late in-the-bag dislocations are inferior, heavier IOLs may lead to higher stress on zonule fibers. Therefore, in patients at risk of developing late in-the-bag IOL dislocation, acrylic hydrophilic and plate-haptic design IOLs should be avoided.

Our study has several limitations. First of all, as the anterior chamber is filled with aqueous humor, density might be a better variable to evaluate than weight. However, we do not believe so, as the IOL is supported by capsular contraction and adherence once the IOL is implanted. Second, to support our recommendations, we should know what types of IOL subluxate the most in proportion to the total implanted, something currently unknown.

Data Availability

The IOL weight data used to support the findings of this study are included within the article.

Conflicts of Interest

The authors declare that they have no conflicts of interest.


  1. S. L. Pueringer, D. O. Hodge, and J. C. Erie, “Risk of late intraocular lens dislocation after cataract surgery, 1980-2009: a population-based study,” American Journal of Ophthalmology, vol. 152, no. 4, pp. 618–623, 2011. View at: Publisher Site | Google Scholar
  2. F. J. Ascaso, V. Huerva, and A. Grzybowski, “Epidemiology, etiology, and prevention of late IOL-capsular bag complex dislocation: review of the literature,” Journal of Ophthalmology, vol. 2015, Article ID 805706, 2015. View at: Publisher Site | Google Scholar
  3. D. Davis, J. Brubaker, L. Espandar et al., “Late in-the-bag spontaneous intraocular lens dislocation,” Ophthalmology, vol. 116, no. 4, pp. 664–670, 2009. View at: Publisher Site | Google Scholar
  4. K. Hayashi, A. Hirata, and H. Hayashi, “Possible predisposing factors for in-the-bag and out-of-the-bag intraocular lens dislocation and outcomes of intraocular lens exchange surgery,” Ophthalmology, vol. 114, no. 5, pp. 969–975, 2007. View at: Publisher Site | Google Scholar
  5. P. Vazquez-Ferreiro, F. J. Carrera-Hueso, N. Fikri-Benbrahim, L. Barreiro-Rodriguez, M. Diaz-Rey, and M. A. Ramón Barrios, “Intraocular lens dislocation in pseudoexfoliation: a systematic review and meta-analysis,” Acta Ophthalmologica, vol. 95, no. 3, pp. e164–e169, 2017. View at: Publisher Site | Google Scholar
  6. A. E. Østern, G. F. Sandvik, and L. Drolsum, “Late in-the-bag intraocular lens dislocation in eyes with pseudoexfoliation syndrome,” Acta Ophthalmologica, vol. 92, no. 2, pp. 184–191, 2012. View at: Publisher Site | Google Scholar
  7. R. Lorente, V. De Rojas, P. V. De Parga et al., “Management of late spontaneous in-the-bag intraocular lens dislocation: retrospective analysis of 45 cases,” Journal of Cataract and Refractive Surgery, vol. 36, no. 8, pp. 1270–1282, 2010. View at: Publisher Site | Google Scholar
  8. Editorial, “Current status of intraocular lenses,” British Journal of Ophthalmology, vol. 61, pp. 307–309, 1977. View at: Publisher Site | Google Scholar
  9. A. Meduri, A. A. Severo, A. De Maria et al., “PMMA intraocular lenses changes after treatment with Nd:Yag laser: a scanning electron microscopy and X-ray spectrometry study,” Applied Sciences, vol. 10, no. 18, p. 6321, 2020. View at: Publisher Site | Google Scholar
  10. H. V. Gimbel, G. P. Condon, T. Kohnen, R. J. Olson, and I. Halkiadakis, “Late in-the-bag intraocular lens dislocation: incidence, prevention, and management,” Journal of Cataract and Refractive Surgery, vol. 31, no. 11, pp. 2193–2204, 2005. View at: Publisher Site | Google Scholar
  11. S. Subasi, N. Yuksel, V. L. Karabas, and B. Yilmaz Tugan, “Late in-the-bag spontaneous IOL dislocation: risk factors and surgical outcomes,” International Journal of Ophthalmology, vol. 12, no. 6, pp. 954–960, 2019. View at: Publisher Site | Google Scholar
  12. L. Werner, S. K. Pandey, M. Escobar-Gomez, N. Visessook, Q. Peng, and D. J. Apple, “Anterior capsule opacification11The authors have no financial or proprietary interest in any product mentioned in this paper,” Ophthalmology, vol. 107, no. 3, pp. 463–471, 2000. View at: Publisher Site | Google Scholar
  13. R. M. Menapace, “Prevention of posterior capsule opacification,” in Cataract and Refractive Surgery, T. Kohnen and D. D. Koch, Eds., pp. 101–122, Springer-Verlag, Berlin, Germany, 2005. View at: Google Scholar
  14. C.-K. Joo, J.-A. Shin, and J.-H. Kim, “Capsular opening contraction after continuous curvilinear capsulorhexis and intraocular lens implantation,” Journal of Cataract and Refractive Surgery, vol. 22, no. 5, pp. 585–590, 1996. View at: Publisher Site | Google Scholar
  15. L. Werner, S. K. Pandey, D. J. Apple, M. Escobar-Gómez, L. McLendon, and T. A. Macky, “Anterior capsule opacification,” Ophthalmology, vol. 108, no. 9, pp. 1675–1681, 2001. View at: Publisher Site | Google Scholar
  16. S. P. Gallagher and M. A. Pavilack, “Risk factors for anterior capsule contraction syndrome with polypropylene or poly (methyl methacrylate) haptics12,” Journal of Cataract & Refractive Surgery, vol. 25, no. 10, pp. 1356–1361, 1999. View at: Publisher Site | Google Scholar
  17. S. Sacu, R. Menapace, W. Buehl, G. Rainer, and O. Findl, “Effect of intraocular lens optic edge design and material on fibrotic capsule opacification and capsulorhexis contraction,” Journal of Cataract and Refractive Surgery, vol. 30, no. 9, pp. 1875–1882, 2004. View at: Publisher Site | Google Scholar
  18. K. Lenis and B. Philipson, “Lens epithelial growth on the anterior surface of hydrogel IOLs, an in vivo study,” Acta Ophthalmologica Scandinavica, vol. 76, no. 2, pp. 184–187, 1998. View at: Publisher Site | Google Scholar
  19. K. Hayashi and H. Hayashi, “Intraocular lens factors that may affect anterior capsule contraction,” Ophthalmology, vol. 112, no. 2, pp. 286–292, 2005. View at: Publisher Site | Google Scholar
  20. H. V. Gimbel and R. Sun, “Role of capsular tension rings in preventing capsule contraction,” Journal of Cataract and Refractive Surgery, vol. 26, no. 6, pp. 791-792, 2000. View at: Publisher Site | Google Scholar
  21. C. S. C. Liu and H. Eleftheriadis, “Multiple capsular tension rings for the prevention of capsular contraction syndrome,” Journal of Cataract and Refractive Surgery, vol. 27, no. 3, pp. 342-343, 2001. View at: Publisher Site | Google Scholar
  22. F. S. Jehan, N. Mamalis, and A. S. Crandall, “Spontaneous late dislocation of intraocular lens within the capsular bag in pseudoexfoliation patients,” Ophthalmology, vol. 108, no. 10, pp. 1727–1731, 2001. View at: Publisher Site | Google Scholar
  23. R. Fernández-Buenaga, J. L. Alio, A. L. Pérez-Ardoy et al., “Late in-the-bag intraocular lens dislocation requiring explantation: risk factors and outcomes,” Eye, vol. 27, no. 7, pp. 795–802, 2013. View at: Publisher Site | Google Scholar

Copyright © 2021 Ángel López-Vázquez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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