Human Platelets Take up Anti-VEGF Agents

Figure 7

Colocalization of anti-VEGF agents and clathrin using double immunogold staining in vesicles (a–c) and alpha-granules (d–f) of human platelets. Large gold particle (12 nm)-labeled anti-VEGF agents and small gold particle (6 nm)-labeled clathrin: (a, g, d, j) ranibizumab; (b, h, e, k) aflibercept; (c, i, f, l) bevacizumab. Scale bar represents 1 µm.