Research Article
Challenges in Patients with Trisomy 21: A Review of Current Knowledge and Recommendations
Table 1
Summary of publications of patients with trisomy 21.
| | Stirn Kranjc [2] | Ljubic et al. [4] | Akinci et al. [3] | Fimiani et al. [5] | Berk et al. [6] | da Cunha and De Castro Moreira [7] | Caputo et al. [8] | Tomita et al. [9] | Liza-Sharmini et al. [11] | Schneier et al. [12] | Jaeger [13] | Kim et al. [10] | Our study |
| | Number of patients (age in years) | 65 (0.2–13) | 170 (1–34) | 77 (1–17) | 157 (0.1–64) | 55 (NA) | 152 (0.16–18) | 187 (NA) | 304 (7.4) | 60 (1–34) | 793 (1–17) | 75 (15–64) | 123 (0.5–14) | 52 (0.2–35) | | Hyperopia (%) | 36.9 | NA | 62.3 | 59 | 52.7 | 26 | 20.9 | 69.1 | 25 | 62.3 | 13 | 28 | 26 | | Astigmatism (%) | 29.2 | 72.4 | 59.7 | 28 | 12.7 | 60 | 22 | 58.5 | 8.3 | 59.7 | NA | 31 | 54 | | Myopia (%) | 24.6 | NA | 7.8 | 9 | 12.7 | 13 | 22.5 | NA | 29.2 | 7.8 | 14 | 25 | 15 | | Strabismus (%) | 26.1 | 26.5 | 32.5 | 36 | 21.8 | 38 | 57 | 36.5 | 26.7 | 32.5 | 41.3 | 25 | 38 | | Congenital cataract (%) | 12.3 | NA | 5.1 | 11 | 20 | 13 | NA | 10.5 | 13.3 | 5.1 | NA | 13 | 5 | | Retinal anomalies (%) | 32.2 | NA | NA | 6 | 38.1 | 28 | NA | NA | 1.7 | NA | NA | 15 | 9 | | Optic nerve anomalies (%) | NA | NA | NA | NA | NA | NA | NA | 1.6 | NA | 3 | NA | NA | NA |
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