Research Article

Preliminary Characterization of Predictive Factors of the Visual Change after Epi-On and Epi-Off Corneal Collagen Crosslinking Techniques

Table 5

Differences between epi-on and epi-off groups in corneal topometric parameters in the different visits of the follow-up.

Mean (SD)Preoperative- valuePostoperative 3 months- valuePostoperative 12 months- value
Median (Range)Epi-onEpi-offEpi-onEpi-offEpi-onEpi-off

Anterior total RMS (μm)15.84 (5.35)12.93 (6.10)0.01315.63 (5.38)12.30 (5.73)0.01815.00 (6.19)11.71 (6.14)0.045
15.14 (22.97)12.33 (28.58)15.01 (22.33)12.09 (26.45)13.71 (23.21)11.44 (28.01)
Anterior HOA RMS (μm)4.06 (1.43)3.32 (1.68)0.0424.04 (1.50)3.14 (1.45)0.0223.84 (1.63)3.01 (1.52)0.048
4.03 (6.14)3.09 (8.39)4.12 (5.99)3.05 (7.17)3.40 (5.75)3.00 (7.64)
Anterior LOA RMS (μm)15.30 (5.19)12.49 (5.89)0.01415.09 (5.19)11.88 (5.57)0.01914.49 (5.99)11.34 (5.98)0.048
14.84 (22.26)11.91 (27.33)14.50 (21.64)11.72 (25.47)13.36 (22.82)11.01 (27.02)
Anterior (μm)−3.14 (1.68)−2.51 (1.75)0.075−3.08 (1.67)−2.48 (1.63)0.125−2.93 (1.78)−2.36 (1.67)0.239
−3.38 (7.03)−2.55 (8.82)−3.16 (7.03)−2.62 (8.31)−2.63 (6.14)−2.60 (8.60)
Anterior Z31 (μm)−0.07 (1.49)0.08 (0.87)0.397−0.13 (1.57)0.04 (0.82)0.3980.00 (1.51)0.02 (0.83)0.861
−0.36 (5.38)0.13 (3.96)−0.42 (7.08)0.13 (3.49)−0.30 (5.32)0.08 (3.36)
Anterior (μm)−0.86 (0.99)−0.47 (0.92)0.116−0.88 (0.95)−0.56 (0.84)0.189−0.85 (1.00)−0.45 (0.87)0.131
−0.79 (4.34)−0.28 (3.33)−0.97 (3.74)−0.49 (2.95)−0.81 (3.94)−0.16 (3.29)
Posterior total RMS (μm)3.66 (1.19)2.87 (1.32)0.0103.61 (1.33)2.86 (1.16)0.0243.45 (1.52)3.17 (2.75)0.816
3.48 (4.70)2.83 (5.94)3.09 (4.75)2.79 (5.54)2.94 (6.34)2.60 (15.40)
Posterior HOA RMS (μm)0.77 (0.48)0.64 (0.34)0.1621.08 (0.37)0.81 (0.32)0.0051.04 (0.45)0.88 (0.67)0.048
0.76 (0.83)0.47 (1.11)0.94 (1.54)0.79 (1.62)0.89 (1.70)0.73 (3.70)
Posterior LOA RMS (μm)3.49 (1.15)2.74 (1.27)0.0133.44 (1.28)2.74 (1.12)0.0443.28 (1.46)3.05 (2.67)0.860
3.38 (4.49)2.66 (5.69)2.97 (4.58)2.68 (5.36)2.83 (6.15)2.47 (15.01)
Posterior (μm)0.76 (0.41)0.58 (0.37)0.0810.77 (0.43)0.59 (0.37)0.0720.72 (0.46)0.58 (0.37)0.309
0.74 (1.68)0.57 (1.74)0.71 (1.78)0.61 (1.73)0.64 (1.72)0.65 (1.70)
Posterior (μm)0.02 (0.41)−0.02 (0.24)0.6670.02 (0.44)−0.01 (0.23)0.554−0.01 (0.40)0.00 (0.23)0.891
0.09 (1.48)0.00 (1.04)0.05 (1.98)−0.03 (0.95)−0.01 (1.53)−0.01 (1.00)
Posterior (μm)0.11 (0.22)0.07 (0.23)0.3860.10 (0.20)0.07 (0.19)0.4620.10 (0.23)0.04 (0.17)0.298
0.11 (0.92)0.03 (1.06)0.12 (0.76)0.07 (0.80)0.11 (1.13)0.04 (0.82)

RMS: root mean square, HOA: higher order aberrations, LOA: lower order aberrations; : vertical coma; : horizontal coma; : spherical aberration.