Comparisons of Vitreal Angiogenic, Inflammatory, Profibrotic Cytokines, and Chemokines Profile between Patients with Epiretinal Membrane and Macular Hole
Table 2
Comparisons of 52 vitreal cytokines between iERMs and iMHs.
Cytokine
iERM
iMH
value
Mean (pg/mL)
SD
Se
Mean (pg/mL)
SD
Se
Angiopoietin-2
93.17
49.34
17.44
123.87
116.90
33.75
0.97
CXCL12
539.87
126.12
44.59
582.49
157.83
45.56
0.53
CXCL9
135.57
94.06
42.06
114.76
51.79
14.95
0.96
Endostatin
62,975.80
12,018.00
4,249.01
57,561.62
17,190.33
4,962.42
0.45
FGF acidic
36.96
3.98
1.41
37.45
4.15
1.20
0.80
FGF basic
4.41
2.27
0.63
5.83
1.19
0.24
0.08
G-CSF
3.73
0.28
0.10
3.79
0.43
0.12
0.91
GM-CSF
M-CSF
154.86
62.47
22.08
141.57
98.68
28.49
0.74
MIF
7,995.97
3,911.00
1,382.75
11,903.57
12,912.18
3,727.43
0.85
MMP-1
50.97
18.08
6.39
41.24
21.25
6.13
0.43
MMP-3
190.62
178.07
62.96
160.49
112.80
32.56
0.65
MMP-7
196.21
69.45
24.56
281.02
215.86
62.31
0.57
MMP-8
342.45
42.58
15.05
221.51
93.32
26.94
0.00
PDGF-AB
41.87
17.61
6.23
27.66
17.71
5.11
0.07
PDGF-DD
PDGF-bb
5.63
2.12
0.75
6.66
2.14
0.62
0.52
PLGF
2.97
2.84
0.79
2.34
1.53
0.31
0.91
Periostin
2,615.99
4,663.18
2,085.44
582.38
344.35
99.41
0.65
Eotaxin
4.12
1.05
0.37
5.14
1.94
0.56
0.03
IFN-g
43.06
9.75
2.70
51.32
24.47
5.00
0.20
IP-10
884.75
1,071.70
297.24
1,032.97
920.38
187.87
0.34
MCP-1
136.27
27.54
9.74
149.56
46.91
13.54
0.48
MIP-1a
0.25
0.05
0.02
0.29
0.05
0.01
0.04
MIP-1b
1.70
0.74
0.20
2.04
1.25
0.36
0.68
RANTES
1.30
0.19
0.07
1.71
0.35
0.10
0.00
TNF-a
1.54
0.51
0.18
1.65
0.51
0.15
0.68
TGF-β1
363.34
155.10
43.02
362.57
155.24
31.69
0.98
TGF-β2
587.05
88.89
24.65
458.65
117.30
23.94
0.01
TGF-β3
1.91
0.70
0.19
1.60
0.57
0.12
0.15
VASH2
0.08
0.01
0.01
0.08
0.02
0.01
0.77
CTGF
13.30
4.43
1.23
12.90
6.17
1.32
0.60
VEGF-A
24.06
21.43
9.59
17.69
6.99
2.02
0.36
VEGF-B
0.04
0.02
0.01
1.00
2.68
0.95
0.82
VEGF-C
446.85
290.81
80.66
488.22
202.90
41.42
0.62
VEGF-D
113.07
61.02
16.92
101.15
85.30
17.48
0.28
IL-1β
0.07
0.01
0.00
0.10
0.05
0.01
0.06
IL-1ra
10.14
5.33
1.48
17.07
20.70
4.22
0.91
IL-2
0.19
0.10
0.04
0.26
0.09
0.03
0.15
IL-4
0.11
0.02
0.01
0.18
0.07
0.02
0.00
IL-5
IL-6
13.72
22.66
10.13
9.64
17.93
5.18
0.65
IL-7
16.13
6.36
2.25
15.48
5.43
1.57
0.68
IL-8
113.07
61.02
16.92
101.15
85.63
17.48
0.28
IL-9
0.08
0.10
0.06
0.27
0.24
0.07
0.23
IL-10
IL-12
0.16
0.00
0.00
0.23
0.14
0.04
0.38
IL-13
0.48
0.38
0.14
0.48
0.33
0.11
1.00
IL-15
IL-17A
0.89
0.70
0.19
0.78
0.39
0.08
0.89
IL-18
69.45
35.09
9.73
57.16
15.62
3.19
0.31
NLRP3
5.35
2.03
1.01
4.72
1.97
0.74
0.65
The cytokine concentrations lay below the limits of detection; ; however, these differences were not significant after Bonferroni correction ( as statistically significant).
