OCT Biomarkers in Neovascular Age-Related Macular Degeneration: A Narrative Review

Table 1

Summary of OCT biomarkers and prognostic value.

Biomarker		Role
Central retinal thickness		Limited prognostic value for visual acuity; If increased correlation with lesion activity is higher
Distribution of retinal fluids	Intraretinal fluids (IRC)	Negative prognostic value for VA
	Subretinal fluids (SRF)	Role debated; Protective for VA if chronic; Related to a stable disease; More treatments needed
	Sub-RPE fluids	No prognostic value for VA
Structural alterations	Subretinal hyperreflective material (SRHM)	Negative prognostic value, in particular if persistent after anti-VEGF therapy
	Outer retinal tubulation (ORT)	Associated to worse visual prognosis
	Photoreceptor layer damage	Negative prognosis on visual acuity
	Vitreomacular interface	VMA and VMT: more intravitreal treatments needed; No prognostic value for visual acuity
	Hyperreflective dots	Related to activity of the lesion and its recurrences
	RPE rips	Negative prognostic value in particular if subfoveal
	Choroidal morphology	Choroidal thickness: no prognostic value on VA; Prechoroidal clefts: risk for REP rips