Review Article
OCT Biomarkers in Neovascular Age-Related Macular Degeneration: A Narrative Review
Table 1
Summary of OCT biomarkers and prognostic value.
| Biomarker | Role |
| Central retinal thickness | | Limited prognostic value for visual acuity If increased correlation with lesion activity is higher | Distribution of retinal fluids | Intraretinal fluids (IRC) | Negative prognostic value for VA | Subretinal fluids (SRF) | Role debated Protective for VA if chronic Related to a stable disease More treatments needed | Sub-RPE fluids | No prognostic value for VA | Structural alterations | Subretinal hyperreflective material (SRHM) | Negative prognostic value, in particular if persistent after anti-VEGF therapy | Outer retinal tubulation (ORT) | Associated to worse visual prognosis | Photoreceptor layer damage | Negative prognosis on visual acuity | Vitreomacular interface | VMA and VMT: more intravitreal treatments needed No prognostic value for visual acuity | Hyperreflective dots | Related to activity of the lesion and its recurrences | RPE rips | Negative prognostic value in particular if subfoveal | Choroidal morphology | Choroidal thickness: no prognostic value on VA Prechoroidal clefts: risk for REP rips |
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