The Efficacy of Clinical Tests to Diagnose Evaporative Dry Eye Disease Related to Meibomian Gland Dysfunction
Table 2
Descriptive and inferential statistical data (OD data only); independent sample analysis.
Test parameter
Scale range
Normal median (IQR) or mean (SD)
EDED median (IQR) or mean (SD)
Significancea (95% CI)
Marginal Signs Normal (n = 94) EDE (n = 93)
0–5
3 (2–4)
5 (3.25–5)
; OR = 1.02 (CI = 0.54–1.91)b
Gland Secretion Normal (n = 136) EDE (n = 228)
0–3
1.0 (0.6)
1.6 (0.6)
(−0.67 to −0.40)b,c
Gland atrophy (meiboscopy) Normal (n = 100) EDE (n = 229)
0–4
1.0 (0.6)
1.4 (0.8)
(−0.56 to −0.18)b
MGD specific Questionnaire Normal (n = 57) EDE (n = 88)
0–174
55.1 (42)
69.4 (38)
(−20.22–5.99)c
Interferometry Normal (n = 85) EDE (n = 190)
1–5
2.32 (0.6)
2.49 (0.7)
(−0.29–0.05)b,c
aNormal vs. EDED; polytomous logistic regression (ordinal data) or multivariable regression analysis (continuous data; Tukey simultaneous tests, controlled for age and gender; values adjusted for multiple comparisons). bSignificant for age ().cSignificant for sex ().