The Efficacy of Clinical Tests to Diagnose Evaporative Dry Eye Disease Related to Meibomian Gland Dysfunction

Table 2

Descriptive and inferential statistical data (OD data only); independent sample analysis.

Test parameter	Scale range	Normal median (IQR) or mean (SD)	EDED median (IQR) or mean (SD)	Significance^a (95% CI)
Marginal Signs; Normal (n = 94); EDE (n = 93)	0–5	3 (2–4)	5 (3.25–5)	; OR =; 1.02; (CI = 0.54–1.91)^b
Gland Secretion; Normal (n = 136); EDE (n = 228)	0–3	1.0 (0.6)	1.6 (0.6)	(−0.67 to −0.40)^b,c
Gland atrophy (meiboscopy); Normal (n = 100); EDE (n = 229)	0–4	1.0 (0.6)	1.4 (0.8)	(−0.56 to −0.18)^b
MGD specific Questionnaire; Normal (n = 57); EDE (n = 88)	0–174	55.1 (42)	69.4 (38)	(−20.22–5.99)^c
Interferometry; Normal (n = 85); EDE (n = 190)	1–5	2.32 (0.6)	2.49 (0.7)	(−0.29–0.05)^b,c

^aNormal vs. EDED; polytomous logistic regression (ordinal data) or multivariable regression analysis (continuous data; Tukey simultaneous tests, controlled for age and gender; values adjusted for multiple comparisons). ^bSignificant for age (). ^cSignificant for sex ().