Research Article

Longitudinal Alterations of Retinal and Choroidal Structure in Patients Recovered from COVID-19

Table 1

Retinal parameter over the study period.

Baseline thickness (µm)1st month thickness (µm)3rd month thickness (µm)P

FoveaFull retina249.7 ± 13.6251.5 ± 14.8246.7 ± 33.4T = 0.43
Inner retina68.3 ± 8.169.2 ± 8.570.1 ± 7.3T = 0.72
Outer retina181.5 ± 8.2181.9 ± 8.1182.8 ± 8.0T = 0.56

Parafovea fullWhole308.6 ± 12.8310.5 ± 12.9313.9 ± 13.9T = 0.16
Sup. hemisphere309.9 ± 13.1310.7 ± 12.9313.1 ± 13.7T = 0.058
Inf. hemisphere308.8 ± 13.2309.1 ± 12.6311.9 ± 13.1T = 0.06
Temporal300.3 ± 12.2301.0 ± 11.8303.5 ± 12.5T = 0.18
Superior314.5 ± 13.1315.5 ± 11.1317.3 ± 14.2T = 0.17
Nasal311.5 ± 11.9312.2 ± 14.7315.4 ± 14.8T = 0.08
Inferior311.4 ± 13.2311.1 ± 12.5313.6 ± 13.2T = 0.21

Inner retinaWhole129.3 ± 7.4128.8 ± 7.6128.8 ± 7.9T = 0.19
Sup. hemisphere129.2 ± 6.8129.3 ± 8.1128.3 ± 8.1T = 0.21
Inf. hemisphere128.9 ± 7.9127.8 ± 8.3127.9 ± 8.2T = 0.21
Temporal121.1 ± 7.03119.3 ± 7.4119.9 ± 7.0T = 0.12
Superior133.1 ± 7.1134.0 ± 8.9132.3 ± 8.9T = 0.14
Nasal129.5 ± 9.9129.9 ± 10.3129.1 ± 10.2T = 0.65
Inferior132.3 ± 8.02131.1 ± 8.5131.1 ± 8.7T = 0.23

Outer retinaWhole179.5 ± 6.7181.3 ± 7.2184.3 ± 8.1T = 0.12
Sup. hemisphere180.8 ± 8.1181.7 ± 6.7184.8 ± 7.9T = 0.18
Inf. hemisphere179.8 ± 7.5181.2 ± 8.0183.9 ± 8.8T = 0.08
Temporal179.1 ± 7.4181.7 ± 7.2183.4 ± 7.8T = 0.08
Superior181.4 ± 8.4181.5 ± 6.5185.1 ± 8.5T = 0.07
Nasal182.0 ± 9.7182.5 ± 8.8186.3 ± 10.6T = 0.06
Inferior179.0 ± 7.9180.0 ± 8.3182.6 ± 9.8T = 0.09

Perifovea fullWhole283.3 ± 10.1282.6 ± 11.8287.7 ± 11.3T = 0.16
Sup. hemisphere286.9 ± 11.3286.5 ± 11.1289.1 ± 11.2T = 0.18
Inf. hemisphere282.3 ± 11.6289.2 ± 10.5283.7 ± 11.9T = 0.59
Temporal274.4 ± 9.9277.9 ± 9.7277.4 ± 9.9T = 0.14
Superior286.5 ± 11.3288.5 ± 10.4288.6 ± 11.3T = 0.21
Nasal300.1 ± 14.8301.5 ± 14.2301.3 ± 14.3T = 0.24
Inferior277.5 ± 11.7278.6 ± 12.8278.4 ± 11.9T = 0.37

Inner retinaWhole113.7 ± 5.1112.8 ± 5.9113.4 ± 5.9T = 0.19
Sup. hemisphere113.8 ± 5.2114.9 ± 5.9113.3 ± 7.8T = 0.24
Inf. hemisphere113.9 ± 5.0113.4 ± 6.4111.9 ± 6.3T = 0.28
Temporal108.3 ± 4.3108.1 ± 4.6107.3 ± 4.4T = 0.22
Superior112.5 ± 4.9113.8 ± 5.9113.1 ± 12.9T = 0.27
Nasal123.0 ± 8.1123.9 ± 8.7120.1 ± 9.5T = 0.18
Inferior111.3 ± 5.7110.9 ± 6.5109.9 ± 6.2T = 0.11

Outer retinaWhole170.1 ± 6.9171.3 ± 6.6174.4 ± 8.4T = 0.12
Sup. hemisphere172.9 ± 8.5174.4 ± 6.4175.9 ± 10.2T = 0.08
Inf. hemisphere168.5 ± 7.1170.7 ± 7.4171.9 ± 8.5T = 0.09
Temporal166.0 ± 7.3169.7 ± 6.9170.0 ± 7.3T = 0.09
Superior173.8 ± 7.6174.7 ± 6.2175.4 ± 15.1T = 0.11
Nasal177.0 ± 9.7177.7 ± 9.3181.1 ± 12.0T = 0.21
Inferior166.3 ± 7.2167.7 ± 7.6168.9 ± 8.5T = 0.22

Based on the generalized estimating equation (GEE). SD: standard deviation.