|
| Angiogenic factors | Connexin type | Comment |
|
| VEGF [52] | Cx43 GJIC | Activation of VEGFR2 by VEGF-E alone inhibited GJIC |
| VEGF [48] | Cx43 GJIC | EGF promoted GJIC in glioblastoma multiforme cells |
| VEGF [48] | Cx43 GJ | VEGF increased the expression of gap junction proteins in U-251 glioblastoma multiforme cells |
| VEGF [39] | Cx43 | VEGF enhanced the expression of Cx43 in endothelial progenitor cells |
| VEGF [51] | Cx43 GJ | Exposure of primary porcine pulmonary artery endothelial cells to VEGF markedly suppressed Cx43 GJs within 1 hour |
| VEGF [52] | Cx43 GJ | VEGF induced Cx43 phosphorylation leading to a decline in pregnancy-adapted Ca2+ burst function |
| VEGF [49] | Cx43 | VEGF120 increased expression of Cx43 in heart |
| VEGF [50] | Cx43 GJIC | VEGF improved intercellular communication at the Cx43 gap junction |
| VEGF [54] | Cx43 GJIC | In coronary capillary endothelium, VEGF disrupted intercellular communication and promoted Cx43 endocytosis and phosphorylation at the Cx43 gap junction |
| VEGF [53] | Cx43 GJIC | VEGF induced phosphorylation of connexin 43 to regulate gap junction intercellular communication in HUVECs |
| VEGF [55] | Cx43 GJIC | VEGF reversibly inhibited GJIC function in EA.hy926 cells and HUVECs |
| bFGF and LPS [57] | Cx43 GJ and HC | Inhibited Cx43 gap junctions but stimulated hemichannels in C6 glioma cells |
| bFGF and LPS [57] | Cx43 GJ and HC | Inhibited Cx43 hemichannels function in HeLa cells. |
| bFGF and VEGF [58] | Cx43 GJIC | Acted as angiogenic factors to increase gap junction heterocellular communication between endothelial cells and hematologic malignant cells |
| bFGF [59] | Cx43 expression and GJIC | bFGF stimulated GJIC and promoted Cx43 expression in skin fibroblasts |
| bFGF [60] | Cx43 expression and GJIC | bFGF stimulation increased Cx43 expression and GJIC in cortical progenitor cells |
| bFGF [61] | Cx43 expression and GJIC | bFGF stimulation increased Cx43 expression and GJIC in cardiac fibroblasts |
| TNF-α [62] | Cx43 HC | Under high glucose conditions, TNF-α increased Cx43 hemichannel function in EA.hy926 cells |
| TNF-α [63] | Cx43 GJ and GJIC | TNF-α decreased the amount of Cx43 gap junction protein and GJIC in corneal fibroblasts |
| TNF-α [64] | Cx43 GJIC | TNF-α decreased Cx43 GJIC in ovine uterine artery endothelial cells and HUVECs |
| MMP9 [65] | Cx43 | The hypoxia-induced downregulation of Cx43 protein was markedly attenuated by doxycycline, an inhibitor of MMP |
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