Relationship of Retinal Vessel Caliber with Age-Related Macular Degeneration

Table 3

Retinal vascular parameters associated with AMD severity.

Factor	Category/increment	AMD severity score (n = 1143)			Presence of CNV (n = 139)			Presence of CGA (n = 21)
		B	95% CI	value	B	95% CI	value	B	95% CI	value
Univariate
Age	1 year	0.102	0.049, 0.155	<0.001	0.052	0.017, 0.087	0.003	−0.023	−0.125, 0.078	0.651
Sex	Female vs. male	−0.068	−0.376, 0.240	0.663	−0.018	−0.401, 0.364	0.926	−0.267	−1.134, 0.601	0.547
Smoking status	Never	Ref			Ref			Ref
	Former	0.365	−0.175, 0.905	0.185	−0.064	−0.419, 0.291	0.723	−	−1.041, 0.760	0.759
	Current	1.071	0.189, 1.953	0.017	0.281	−0.261, 0.822	0.310	−0.018	−1.535, 1.500	0.982
Cilioretinal artery	Present vs. absent	−1.009	−1.546, −0.473	<0.001	−0.721	−1.257, −0.186	0.008	−0.081	−1.169, 1.006	0.883
CRAE	1 mm	−0.008	−0.022, 0.006	0.240	−0.001	−0.011, 0.009	0.821	−0.026	−0.045, −0.007	0.007
CRVE	1 mm	0.005	−0.010, 0.020	0.500	0.005	−0.005, 0.015	0.343	−0.022	−0.051, 0.007	0.132
AVR	—	−4.853	−9.148, 0.559	0.027	−1.940	−5.381, 1.500	0.269	−5.794	−11.48, −0.112	0.046
Multivariate
Age	1 year	0.104	0.053, 0.155	<0.001	0.052	0.017, 0.087	0.003
Smoking status	Never	Ref
	Former	0.299	−0.242, 0.841	0.278
	Current	1.109	0.246, 1.971	0.012
Cilioretinal artery	Present vs. absent	−0.909	−1.439, −0.378	0.001	−0.720	−1.256, −0.183	0.009
AVR		−4.592	−8.842, −0.342	0.034

AMD, age-related macular degeneration; CNV, choroidal neovascularization; CGA, central geographic atrophy; B, beta coefficient; CI, confidence interval; CRAE, central retinal arteriolar equivalent; CRVE, central retinal venular equivalent; AVR, arteriole-to-venule ratio.