Journal of Ophthalmology

Retinal Biomarkers and Predictors in the Era of Multimodal Imaging

Publishing date
01 Jan 2022
Submission deadline
10 Sep 2021

1Sapienza University of Rome, Rome, Italy

2Oftalvist Clinic, Valencia, Spain

3University of Yamanashi, Yamanashi, Japan

4Rabin Medical Center, Petah Tikva, Israel

Retinal Biomarkers and Predictors in the Era of Multimodal Imaging

Call for papers

This Issue is now open for submissions.

Papers are published upon acceptance, regardless of the Special Issue publication date.

 Submit to this Special Issue


Multimodal imaging provides an efficient integration of imaging techniques to improve clinical assessment, diagnostic performance, and monitoring of specific morphological and functional findings. The combination of different imaging modalities and technological advances provides further insights in the identification of retinal biomarkers that may serve as the hallmark of specific histopathological features.

These biomarkers help in the early detection of particular ocular and systemic disorders as well as provide predictors for functional and anatomical outcomes or late-stage complications in several retinal and systemic diseases. Retinal biomarkers and predictors have been identified in a myriad of ocular pathologies including age-related macular degeneration, diabetic retinopathy, retinal vein occlusion, uveitis, and glaucoma, but also neurological disorders as Alzheimer’s disease, dementia, and Parkinson’s disease.

The purpose of this Special Issue is to report novel biomarkers and predictors, multimodal characterization, and the potential clinical and prognostic implications in various retinal diseases including age-related macular degeneration, diabetic retinopathy, retinal vascular disease, uveitis, and glaucoma. For this special issue, we encourage original research with innovative and high-quality findings and state-of-the-art review articles.

Potential topics include but are not limited to the following:

  • Identification of novel retinal biomarkers using multimodal retinal imaging
  • Predictive biomarkers for functional and anatomical outcomes in various retinal diseases and glaucomatous optic neuropathies
  • Retinal biomarkers in the early diagnosis of age-related macular degeneration, retinal vascular disease, congenital retinal dystrophies, uveitis, and glaucomatous optic neuropathy
  • Predictive biomarkers of inflammation or disease activity in uveitis
  • Predictive biomarkers of retinal disease progression and/or predicting and monitoring the clinical response to therapy
  • Structure-function correlates serving as predictors for disease progression
  • New multimodal imaging findings distinctive for particular anatomical correlates
  • Retinal biomarkers in neurological disorders


  • Special Issue
  • - Volume 2021
  • - Article ID 9994098
  • - Review Article

OCT Biomarkers in Neovascular Age-Related Macular Degeneration: A Narrative Review

Cristian Metrangolo | Simone Donati | ... | Claudio Azzolini
  • Special Issue
  • - Volume 2021
  • - Article ID 2942197
  • - Research Article

Characterizing Flow and Structure of Diabetic Retinal Neovascularization after Intravitreal Anti-VEGF Using Optical Coherence Tomography Angiography: A Pilot Study

Christof Haensli | Katrin Fasler | ... | Sandrine A. Zweifel
  • Special Issue
  • - Volume 2021
  • - Article ID 8867570
  • - Research Article

Clinical Characteristics of Paracentral Acute Middle Maculopathy in Eyes with Retinal Vascular Occlusion Diseases in Chinese Patients

Zhengwei Zhang | Yunjia Jiang | ... | Bilian Ke
  • Special Issue
  • - Volume 2021
  • - Article ID 6698522
  • - Research Article

Clinical Features, Prognosis, and Long-Term Response to Ranibizumab of Macular CNVs in Pattern Dystrophies Spectrum: A Pilot Study

Lorenzo Casillo | Stefano Tricarico | ... | Enzo M. Vingolo
  • Special Issue
  • - Volume 2021
  • - Article ID 6639418
  • - Research Article

Optical Coherence Tomography Predictors of Favorable Functional Response in Naïve Diabetic Macular Edema Eyes Treated with Dexamethasone Implants as a First-Line Agent

Alessandro Meduri | Giovanni William Oliverio | ... | Costantino John Trombetta
  • Special Issue
  • - Volume 2020
  • - Article ID 8850309
  • - Research Article

Retinal Structural and Microvascular Alterations in Different Acute Ischemic Stroke Subtypes

Ying Zhang | Ce Shi | ... | Meixiao Shen
Journal of Ophthalmology
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Impact Factor1.909

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.