A Longitudinal Study of the Effect of Genistein on Bone in Two Different Murine Models of Diminished Estrogen-Producing Capacity

Table 2

Ex vivo microcomputed tomography measures of bone microarchitectural changes in treated mice.

μCT parameters (units)	Treatments ($n=6$/group)
	SHM	OVX	S + V	O + G	SVG		Pooled SEM	$P$-value
L5 Vertebral body: trabecular
BV/TV, (%)	${18.4}^{\text{a}}$	${12.4}^{\text{c}}$	${15.1}^{\text{ab}}$	${14.5}^{\text{bc}}$	${15.7}^{\text{b}}$		0.6	<0.0001
BV, (mm^3)	${0.472}^{\text{a}}$	${0.354}^{\text{b}}$	${0.394}^{\text{ab}}$	${0.396}^{\text{ab}}$	${0.426}^{\text{ab}}$		0.019	<0.005
Tb.N, (mm^-1)	${3.32}^{\text{a}}$	${2.77}^{\text{b}}$	${2.94}^{\text{ab}}$	${2.76}^{\text{b}}$	${2.97}^{\text{ab}}$		0.116	<0.05
Tb.Th, (μm)	${55}^{\text{a}}$	${47}^{\text{b}}$	${55}^{\text{a}}$	${56}^{\text{a}}$	${55}^{\text{a}}$		1	<0.0001
Tb.Sp, (μm)	305	367	342	367	341		16	NS
Distal femur: trabecular
BV/TV, (%)	2.62	2.05	2.39	1.90	2.00		0.08	NS
BV, (mm^3)	0.066	0.057	0.062	0.46	0.53		0.01	NS
Tb.N, (mm^-1)	2.21	1.94	2.01	1.91	2.07		0.20	NS
Tb.Th, (μm)	41	42	44	43	40		2	NS
Tb.Sp, (μm)	446	522	500	524	483		22	NS
Midshaft femur: cortical
Area (mm^2)	${0.838}^{\text{a}}$	${0.770}^{\text{b}}$	${0.829}^{\text{ab}}$	${0.806}^{\text{ab}}$	${0.837}^{\text{a}}$		0.014	<0.05
Ct.Th, ($\mu$m)	${200}^{\text{a}}$	${176}^{\text{b}}$	${194}^{\text{a}}$	${192}^{\text{a}}$	${196}^{\text{a}}$		0.003	<0.001
BV (mm^3)	${0.242}^{\text{a}}$	${0.222}^{\text{b}}$	${0.239}^{\text{a}}$	${0.231}^{\text{ab}}$	${0.241}^{\text{a}}$		0.004	<0.05

Data represent the group means. $P$-values are for one-way ANOVA tests. Different letters indicate means that are statistically different based on Tukey-Kramer post hoc test.