Journal of Osteoporosis / 2010 / Article / Tab 3

Research Article

A Longitudinal Study of the Effect of Genistein on Bone in Two Different Murine Models of Diminished Estrogen-Producing Capacity

Table 3

Bone length and mechanical strength of the femur and tibia of mice during ex vivo three-point testing.

Parameters, (units)Treatments
SHMOVXS + VO + GSVGP-value

Right Femur(n=11)(n=12)(n=8)(n=14)(n=9)
Bone length, (mm)15.81±0.02b16.26±0.02a15.92±0.02ab16.22±0.03a15.76±0.03b<.0001
Ultimate Force, (N)16.0±0.3a13.4±0.3b16.1±0.6a15.7±0.5a16.6±0.3a<.0001
Failure Force, (N)12.1±1.1a5.8±1.0b9.6±1.7ab9.0±1.1ab11.7±1.7a<0.010
Yield Force, (N)12.3±0.6a10.3±0.4b12.2±0.4ab11.9±0.6ab12.0±2.6ab<0.001
Stiffness, (N/mm)81.4 ± 1.475.8 ± 2.780.2 ± 3.183.0 ± 2.484.4 ± 1.2NS
Energy to Ultimate Force, (mJ)3.1 ± 0.12.7 ± 0.23.0 ± 0.23.0 ± 0.23.3 ± 0.1NS

Left Tibia(n=11)(n=15)(n=12)(n=18)(n=10)
Bone length, (mm)18.08±0.07bc18.38±0.06a18.26±0.03abc18.33±0.06ab18.07±0.04c<0.001
Ultimate Force, (N)10.5 ± 0.29.8 ± 0.210.6 ± 0.210.4 ± 0.310.7 ± 0.4NS
Failure Force, (N)4.9 ± 0.93.7 ± 0.63.3 ± 0.34.5 ± 0.63.7 ± 0.8NS
Yield Force, (N)10.0 ± 0.29.1 ± 0.310.3 ± 029.9 ± 0.310.2 ± 0.4NS
Stiffness, (N/mm)36.2 ±1.135.8 ± 0.839.1 ±1.137.4 ± 0.838.5 ± 0.9NS
Energy to Ultimate Force, (mJ)2.0 ± 0.11.8 ± 0.11.8 ± 0.11.9 ± 0.11.9 ± 0.1NS

Data represent the group means ± SEM. Different letters indicate means that are statistically different. NS indicates not significant. Samples that rolled on the supports during mechanical testing were eliminated from the analyses.

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