Retaining Residual Ovarian Tissue following Ovarian Failure Has Limited Influence on Bone Loss in Aged Mice
Figure 3
Representative two-dimensional frontal planar CT images showing changes in bone integrity of the fifth vertebral body of VCD-treated and ovariectomized mice. Aged C57BL/6Hsd female mice (9–12 months old) were dosed daily for 15 days with sesame oil (vehicle; CON) or VCD (160 mg/kg) or ovariectomized on d35 after the start of the experiment. Trabecular bone microarchitecture of the fifth vertebral body was assessed by CT on samples collected at 5-month postovarian failure (age: 18.8 months; d181) as described in Section 2. Shown are representative images of vertebral bodies excised from: (a) a cycling control-treated, (b) a VCD-treated, and (c) an ovariectomized animal. The scale bar represents 1.0 mm in all images.
