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Journal of Osteoporosis
Volume 2010, Article ID 736391, 10 pages
Research Article

Bone Loss Rate May Interact with Other Risk Factors for Fractures among Elderly Women: A 15-Year Population-Based Study

1Bone and Cartilage Research Unit (BCRU), University of Kuopio, 70211 Kuopio, Finland
2Department of Orthopedics and Traumatology, Kuopio University Hospital, 70211 Kuopio, Finland
3Department of Obstetrics and Gynaecology, Kuopio University Hospital, 70211 Kuopio, Finland
4Department of Clinical Physiology & Nuclear Medicine, Kuopio University Hospital, 70211 Kuopio, Finland
5Department of Surgery, Kuopio University Hospital, 70211 Kuopio, Finland

Received 8 September 2009; Revised 15 November 2009; Accepted 31 December 2009

Academic Editor: Saeko Fujiwara

Copyright © 2010 Joonas Sirola et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim was to investigate fracture risk (FR) according to bone loss (BL) rate. A random sample of 1652 women aged 53.5 years was measured with dual X-ray absorptiometry in femoral neck in 1989 and 1994 and divided into tertiles of annual BL rate: high >0.84%, moderate 0.13%–0.84%, and low <0.13%. Low trauma energy fractures during following 10 years were recorded. There were no differences in FR between BL tertiles in Cox regression model. Factors predicting lower FR in Cox model were in high tertile: high T-score (HR 0.71; 95% CI 0.54–0.93, ), no sister's fracture (HR 0.35; 0.19–0.64, ), no mother's fracture (HR 0.52; 0.31–0.88, ), in moderate tertile: high T-score (HR 0.69;0.53–0.91, ) and good grip strength (HR 0.98; 0.97–0.99, ). In low tertile there were no predictors for FR. BL predicted FR in women with mother's fracture in univariate and multivariate model (OR 2.6; 1.15–5.7, ) but with sister's fracture this was observed only in multivariate model (OR 2.66; 1.09–6.7, ). Accordingly, the risk factors for postmenopausal fractures, especially mother's fracture, may interact with BL.